Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha.
about
The many functions of APE1/Ref-1: not only a DNA repair enzymeEmergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms.Excision repair is required for genotoxin-induced mutagenesis in mammalian cells.Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed.Novel role of base excision repair in mediating cisplatin cytotoxicity.N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomideRemoval of uracil by uracil DNA glycosylase limits pemetrexed cytotoxicity: overriding the limit with methoxyamine to inhibit base excision repair.Downregulation of hPMC2 imparts chemotherapeutic sensitivity to alkylating agents in breast cancer cellsTumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.Pediatric CNS tumors: current treatment and future directions.Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatribGoing ape as an approach to cancer therapeutics.Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation.Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions.Paediatric high and low grade glioma: the impact of tumour biology on current and future therapy.Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.Improved efficacy of acylfulvene in colon cancer cells when combined with a nuclear excision repair inhibitor.Pediatric neuro-oncology: current status and future directions.Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1.Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor.A novel class of chemicals that react with abasic sites in DNA and specifically kill B cell cancers.Targeting base excision repair suggests a new therapeutic strategy of fludarabine for the treatment of chronic lymphocytic leukemia.A versatile new tool to quantify abasic sites in DNA and inhibit base excision repair.Phase I clinical trial of the base excision repair inhibitor methoxyamine in combination with fludarabine for patients with advanced hematologic malignancies.Advances in therapeutic targeting of the DNA damage response in cancer.
P2860
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P2860
Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Combined treatment with temozo ...... rgeting topoisomerase IIalpha.
@en
type
label
Combined treatment with temozo ...... rgeting topoisomerase IIalpha.
@en
prefLabel
Combined treatment with temozo ...... rgeting topoisomerase IIalpha.
@en
P2093
P1476
Combined treatment with temozo ...... rgeting topoisomerase IIalpha.
@en
P2093
Alina Bulgar
Jon R Donze
Stanton L Gerson
Varun Mahajan
Yanling Miao
P304
P356
10.1158/1078-0432.CCR-06-1595
P407
P577
2007-03-01T00:00:00Z