A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.
about
Inward rectifiers and their regulation by endogenous polyaminesMechanism for attenuated outward conductance induced by mutations in the cytoplasmic pore of Kir2.1 channelsCrystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A ResolutionPhysical determinants of strong voltage sensitivity of K+ channel blockStructure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gatingToward understanding the assembly and structure of KATP channelsKir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channelThe tetravalent organic cation spermine causes the gating of the IRK1 channel expressed in murine fibroblast cellsIncreased excitability and inward rectification in layer V cortical pyramidal neurons in the epileptic mutant mouse StargazerThree-dimensional models of non-NMDA glutamate receptorsMulti-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels.Inward rectification in KATP channels: a pH switch in the pore.Spermine is fit to block inward rectifier (Kir) channels.Polyamines as gating molecules of inward-rectifier K+ channels.Cloning and expression of two brain-specific inwardly rectifying potassium channelsA ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.C-terminal determinants of Kir4.2 channel expression.K+ channel selectivity depends on kinetic as well as thermodynamic factors.Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity.Flexibility of the Kir6.2 inward rectifier K(+) channel poreMerging functional studies with structures of inward-rectifier K(+) channels.Revisiting inward rectification: K ions permeate through Kir2.1 channels during high-affinity block by spermidine.Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics.Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6.Mechanism of the voltage sensitivity of IRK1 inward-rectifier K+ channel block by the polyamine spermine.Octameric stoichiometry of the KATP channel complex.Ser165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+.Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels.Pore block versus intrinsic gating in the mechanism of inward rectification in strongly rectifying IRK1 channels.Cytoplasmic amino and carboxyl domains form a wide intracellular vestibule in an inwardly rectifying potassium channel.Kinetics of inward-rectifier K+ channel block by quaternary alkylammonium ions. dimension and properties of the inner porePermeation properties of inward-rectifier potassium channels and their molecular determinantsControl of rectification and gating of cloned KATP channels by the Kir6.2 subunitCarboxy-terminal determinants of conductance in inward-rectifier K channelsLong polyamines act as cofactors in PIP2 activation of inward rectifier potassium (Kir2.1) channelsSpermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore block.Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel
P2860
Q26865121-5413508B-6135-4CC7-AC5A-FB60240F2417Q27303585-04539C11-9C73-4956-A97E-CC7B319219ACQ27646617-5DA95105-1A0E-45D8-9192-DE403529E94BQ27658191-E4045675-AA3E-4942-AD42-B2B2F0EF2CD6Q27676659-39D40907-2ED4-4A51-8F4A-D6DE309AAF7DQ28261116-CE9D019F-95FC-4728-8D24-8457C52E6E6AQ28280421-EEBBE464-7095-49A0-9855-6C09C476302BQ28360309-DA5E1705-9D99-471E-97C8-0E1099D0317AQ28379235-42687ECC-EE8F-4491-A57E-AFF97E6E80F8Q28584777-353875D3-6DD2-41EB-A920-796F18ED92D1Q30177008-521C1507-BF92-4BF2-8AD9-A191CBA9EF1BQ33726168-8B64862D-2B8C-43C3-AC5D-6BEB76041FEFQ33852328-43AA6AE0-21C2-486A-809E-19F146F7E609Q33973477-81A20E0F-1D20-4581-B8ED-FF379110699CQ34039970-8012A1FE-1DC9-4341-AC95-CC12E6CFEBAAQ34075247-6700CECF-836D-46B7-AC08-7349477F8A38Q34188472-5FE7BEA4-FA1E-42E4-81C2-31853E506E9FQ34624123-541BF7EE-09A5-4C14-98BD-3B5704E5D794Q35039379-54706563-BB1E-4AE0-ADEF-E1905EE2140DQ35039384-6BE57AB0-FCE8-4E60-B7BF-4A20A807A24CQ35061235-29EBF862-E5DD-46A6-9D73-313DC2F37A44Q35584086-01295E8F-26E2-46E0-90F0-F42374BC269AQ35791599-47F393FA-76E5-43C7-8726-91383006611DQ36159053-779F8D79-2272-4D51-B2E0-9B3BF585552FQ36295651-BE8D7CB1-79FC-43E4-93B7-6A8FD9CA8F03Q36295697-AFC3BA07-5822-477D-9FB8-A7A0E975BBCBQ36412396-52A04FD7-E485-406D-ADA4-F70C70A3CF53Q36412643-1C91C9C0-08F4-4945-8F52-21F402A357D3Q36436003-FB5F37FE-6196-4D13-ACBB-5F9DBA3284A3Q36436571-B7ED6952-A4E0-47ED-817E-65E1084F68B8Q36436623-514CB7CF-E522-4F63-A2EC-B11FFDD8EFC2Q36438882-983B73A8-3707-4FFB-9134-7F727106B367Q36439784-9970E42A-C751-4BAF-82E6-41F0CEEB1CD7Q36444667-875B5E34-DFA3-4DCD-9872-6B3FFC0737C7Q36444965-C325D2D6-B00A-4236-B7E9-720C8E45D9D5Q36445028-6DD2BEAB-CBD8-40D2-AFB6-27E08847864CQ36445728-9ED887D9-F2BC-4B8A-AD56-73E5F953A24BQ36493585-A6C46142-65EB-4EEB-9D87-CD2A552A08E4Q36558213-26B83431-460D-4C6B-B489-FAF4489ED8EEQ36773504-FF6FC818-C043-459E-B982-A9C2D6348FD7
P2860
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
A single aspartate residue is ...... of the inward rectifier, IRK1.
@en
type
label
A single aspartate residue is ...... of the inward rectifier, IRK1.
@en
prefLabel
A single aspartate residue is ...... of the inward rectifier, IRK1.
@en
P2093
P2860
P1476
A single aspartate residue is ...... of the inward rectifier, IRK1.
@en
P2093
Brammar WJ
Shelton PA
Stanfield PR
Sutcliffe MJ
P2860
P356
10.1113/JPHYSIOL.1994.SP020225
P407
P478
478 ( Pt 1)
P577
1994-07-01T00:00:00Z