Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies.

Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies.

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http://www.wikidata.org/entity/Q38315557
Principles of interleukin (IL)-6-type cytokine signalling and its regulationStructural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activationStructural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane ComplexThe SCHOOL of nature: I. Transmembrane signaling.A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth.A novel type II membrane receptor up-regulated by IFN-alpha in fibroblasts functions in cell proliferation through the JAK-STAT signalling pathway.Identification of agonistic and antagonistic antibodies against gp190, the leukemia inhibitory factor receptor, reveals distinct roles for its two cytokine-binding domains.Replacing factor-dependency with that for lysozyme: affordable culture of IL-6-dependent hybridoma by transfecting artificial cell surface receptor.Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer.Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling.Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis.Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activationDetermination of the Disulfide Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Signal Transducer gp130
P2860

Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies.

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http://www.wikidata.org/entity/Q38315557
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Studies on the interleukin-6-t ...... tion by monoclonal antibodies.
@en
type
label
Studies on the interleukin-6-t ...... tion by monoclonal antibodies.
@en
prefLabel
Studies on the interleukin-6-t ...... tion by monoclonal antibodies.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Studies on the interleukin-6-t ...... tion by monoclonal antibodies.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698