Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies.
about
Principles of interleukin (IL)-6-type cytokine signalling and its regulationStructural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activationStructural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane ComplexThe SCHOOL of nature: I. Transmembrane signaling.A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.Due to interleukin-6 type cytokine redundancy only glycoprotein 130 receptor blockade efficiently inhibits myeloma growth.A novel type II membrane receptor up-regulated by IFN-alpha in fibroblasts functions in cell proliferation through the JAK-STAT signalling pathway.Identification of agonistic and antagonistic antibodies against gp190, the leukemia inhibitory factor receptor, reveals distinct roles for its two cytokine-binding domains.Replacing factor-dependency with that for lysozyme: affordable culture of IL-6-dependent hybridoma by transfecting artificial cell surface receptor.Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer.Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling.Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis.Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activationDetermination of the Disulfide Structure andN-Glycosylation Sites of the Extracellular Domain of the Human Signal Transducer gp130
P2860
Q24530173-A8F4E481-C9A1-451E-8E8F-AB7C6C372117Q24533565-546DAEE4-0F56-4205-94D4-AA4327A3AFF1Q27652013-0753A20A-BCAD-4142-AD05-6B92533FECFAQ33351190-D138E202-CF3D-4A88-9A9E-F3A3C4E2FC2AQ33378529-CE97153A-0A5E-4812-8CF4-97DB7A6640A9Q34182929-AA5D3AE8-99BE-4DDF-B21C-23888D8DC823Q38625843-42216A6B-E874-407F-93BA-CCCBB21DB9D5Q38744300-9C39DE44-DCBE-4923-870E-DE9E1756F689Q40303788-F137AE14-3E25-41F9-B2C4-D47AF9EF17EDQ40773924-4CFE7D5F-D191-41C2-BF89-6CE8BB2E879EQ40796169-4E9199B9-B5C0-489E-B9EC-B297CEC4E5ABQ41829592-7FF115D5-E943-477D-B594-9C2DD96BBCB1Q43993795-852E5040-A16B-486A-BE52-302C211CFF2FQ44524128-3E9328A3-6C06-4A48-AFDF-F15499B3335DQ56531947-B6ABE4E4-E3D7-4DA1-9AD8-0A2C5C0796ABQ58039489-FB96448F-0FE8-4598-BD2E-FAAC4C70692E
P2860
Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Studies on the interleukin-6-t ...... tion by monoclonal antibodies.
@en
type
label
Studies on the interleukin-6-t ...... tion by monoclonal antibodies.
@en
prefLabel
Studies on the interleukin-6-t ...... tion by monoclonal antibodies.
@en
P2093
P2860
P356
P1476
Studies on the interleukin-6-t ...... tion by monoclonal antibodies.
@en
P2093
Heinrich PC
Müller-Newen G
Wijdenes J
P2860
P304
P356
10.1074/JBC.275.7.4579
P407
P577
2000-02-01T00:00:00Z