Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression. - Wikidata - wikimedia - TriplyDB

Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression.

Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression.

http://www.wikidata.org/entity/Q38344348

about

A homeodomain protein binds to gamma-globin gene regulatory sequences Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human gamma and epsilon globin genes Regulatory mutations and human genetic disease.Protein-DNA interactions upstream from the human A gamma globin gene Methylation-enhanced binding of Sp1 to the stage selector element of the human gamma-globin gene promoter may regulate development specificity of expression.Roles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes.Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice.Modulation of the phenotypic diversity of sickle cell anemia.

P2860

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P2860

Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression.

http://www.wikidata.org/entity/Q38344348

description

1989 nî lūn-bûn

@nan

1989年の論文

@ja

1989年論文

@yue

1989年論文

@zh-hant

1989年論文

@zh-hk

1989年論文

@zh-mo

1989年論文

@zh-tw

1989年论文

@wuu

1989年论文

@zh

1989年论文

@zh-cn

name

Mutations in two regions upstr ...... omoter affect gene expression.

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type

label

Mutations in two regions upstr ...... omoter affect gene expression.

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prefLabel

Mutations in two regions upstr ...... omoter affect gene expression.

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Nucleic Acids Research

P1476

Mutations in two regions upstr ...... omoter affect gene expression.

@en

P2093

J A Lloyd

http://www.w3.org/2001/XMLSchema#string

J B Lingrel

http://www.w3.org/2001/XMLSchema#string

R F Lee

http://www.w3.org/2001/XMLSchema#string

P2860

Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes

Rapid and efficient site-specific mutagenesis without phenotypic selection

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains

The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain

Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin.

Erythroid-specific expression of human beta-globin genes in transgenic mice.

DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells.

P304

4339-4352

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scholarly article

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10.1093/NAR/17.11.4339

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11

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17

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1989-06-01T00:00:00Z

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20682745

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2472607

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317938

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