T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice
about
Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapyIkaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongationPurification and identification of proteins that bind to the hereditary persistence of fetal hemoglobin -198 mutation in the gamma-globin gene promoterCTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood.Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.NF-Y recruits both transcription activator and repressor to modulate tissue- and developmental stage-specific expression of human γ-globin gene.Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.Fetal hemoglobin in sickle cell anemiaFetal hemoglobin reactivation and cell engineering in the treatment of sickle cell anemia.Transient expression assay of Agamma-588 (A/G) mutations in the K562 cell line.Global jumping and domain-specific intersegment transfer between DNA cognate sites of the multidomain transcription factor Oct-1.Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia.Natural Remedies for the Treatment of Beta-Thalassemia and Sickle Cell Anemia-Current Status and Perspectives in Fetal Hemoglobin Reactivation.Facilitated DNA search by multidomain transcription factors: cross talk via a flexible linker.Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes.Evidence for a bigenic chromatin subdomain in regulation of the fetal-to-adult hemoglobin switch.T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro.Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness.
P2860
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P2860
T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice
description
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2005
@ast
im März 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/03/04)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/03/04)
@nl
наукова стаття, опублікована в березні 2005
@uk
name
T to C substitution at -175 or ...... n phenotype in transgenic mice
@ast
T to C substitution at -175 or ...... n phenotype in transgenic mice
@en
T to C substitution at -175 or ...... n phenotype in transgenic mice
@nl
type
label
T to C substitution at -175 or ...... n phenotype in transgenic mice
@ast
T to C substitution at -175 or ...... n phenotype in transgenic mice
@en
T to C substitution at -175 or ...... n phenotype in transgenic mice
@nl
prefLabel
T to C substitution at -175 or ...... n phenotype in transgenic mice
@ast
T to C substitution at -175 or ...... n phenotype in transgenic mice
@en
T to C substitution at -175 or ...... n phenotype in transgenic mice
@nl
P2093
P2860
P921
P356
P1476
T to C substitution at -175 or ...... n phenotype in transgenic mice
@en
P2093
Fu-De Fang
Hua-Lu Zhao
Jun-Wu Zhang
Li-Ren Liu
Xiao-Dong Huang
Xiao-Ling Liu
Zhan-Wen Du
P2860
P304
P356
10.1074/JBC.M411407200
P407
P577
2005-03-04T00:00:00Z