The effects of HPFH mutations in the human gamma-globin promoter on binding of ubiquitous and erythroid specific nuclear factors.
about
A homeodomain protein binds to gamma-globin gene regulatory sequencesA novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expressionFetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathiesDNA sequences regulating human globin gene transcription in nondeletional hereditary persistence of fetal hemoglobinT to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic micePhylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human gamma and epsilon globin genesNuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin.Analysis of 5' flanking regions of the gamma globin genes from major African haplotype backgrounds associated with sickle cell disease.Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genesrSNP_Guide: an integrated database-tools system for studying SNPs and site-directed mutations in transcription factor binding sites.Erythropoietin triggers a burst of GATA-1 in normal human erythroid cells differentiating in tissue culture.Regulatory mutations and human genetic disease.Nuclear protein factors and erythroid transcription of the human A gamma-globin geneThe deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement proteinProtein-DNA interactions upstream from the human A gamma globin geneProgressive inactivation of the expression of an erythroid transcriptional factor in GM- and G-CSF-dependent myeloid cell lines.Distal CCAAT box deletion in the A gamma globin gene of two black adolescents with elevated fetal A gamma globin.Roles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes.GATA1 and YY1 are developmental repressors of the human epsilon-globin gene.Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein.A factor binding GATAAG confers tissue specificity on the promoter of the human zeta-globin gene.Mutations in two regions upstream of the A gamma globin gene canonical promoter affect gene expression.Role of NF-Y in in vivo regulation of the gamma-globin geneIncreased erythroid-specific expression of a mutated HPFH gamma-globin promoter requires the erythroid factor NFE-1.An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1.GATAAG; a cis-control region binding an erythroid-specific nuclear factor with a role in globin and non-globin gene expression.In vitro and in vivo protein--DNA interactions on the rat erythroid-specific L' pyruvate kinase gene promoter.Increased Sp1 binding mediates erythroid-specific overexpression of a mutated (HPFH) gamma-globulin promoter.Evidence of the role of protein kinase C during aclacinomycin induction of erythroid differentiation in K562 cells.Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters.Hemoglobin switching in humans is accompanied by changes in the ratio of the transcription factors, GATA-1 and SP1.Differential binding of the NFE3 and CP1/NFY transcription factors to the human gamma- and epsilon-globin CCAAT boxes.
P2860
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P2860
The effects of HPFH mutations in the human gamma-globin promoter on binding of ubiquitous and erythroid specific nuclear factors.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
The effects of HPFH mutations ...... roid specific nuclear factors.
@en
type
label
The effects of HPFH mutations ...... roid specific nuclear factors.
@en
prefLabel
The effects of HPFH mutations ...... roid specific nuclear factors.
@en
P2093
P2860
P356
P1476
The effects of HPFH mutations ...... roid specific nuclear factors.
@en
P2093
Giglioni B
Malgaretti N
Mantovani R
Ottolenghi S
P2860
P304
P356
10.1093/NAR/16.16.7783
P407
P577
1988-08-01T00:00:00Z