c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.
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Ablation of the Sam68 RNA binding protein protects mice from age-related bone lossSrc family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progressionCbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motilityc-Src control of chloride channel support for osteoclast HCl transport and bone resorptionRegulation of cytochrome c oxidase activity by c-Src in osteoclastsA role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophilsIdentification and functional characterization of an Src homology domain 3 domain-binding site on CblRegulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolinCbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cellsThe adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interactionInterleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cellsCoordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinasesThe CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cellsThe Cbl interactome and its functionsSteel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells.SH3P2 in complex with Cbl and Src.The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl.Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylationThe Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.Deficient tyrosine phosphorylation of c-Cbl and associated proteins in phorbol ester-resistant EL4 mouse thymoma cells.A functional link between dynamin and the actin cytoskeleton at podosomes.A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells.Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis.IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis.Commitment and differentiation of stem cells to the osteoclast lineage.Platelet and osteoclast beta3 integrins are critical for bone metastasis.Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceRoles of E3 ubiquitin ligases in cell adhesion and migration.Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction.Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.Regulation of sealing ring formation by L-plastin and cortactin in osteoclasts.Src inhibitors in the treatment of metastatic bone disease: rationale and clinical dataCbl: many adaptations to regulate protein tyrosine kinases.The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival.Beyond the RING: CBL proteins as multivalent adapters.Cell adhesion signaling regulates RANK expression in osteoclast precursors.
P2860
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P2860
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.
@en
type
label
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.
@en
prefLabel
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.
@en
P2093
P356
P1433
P1476
c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption
@en
P2093
P2888
P304
P356
10.1038/383528A0
P407
P50
P577
1996-10-01T00:00:00Z
P6179
1048768730