High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
about
Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinitySpecific dephosphorylation of phosphoproteins by protein-serine and -tyrosine kinases.Structure of the human insulin receptor gene and characterization of its promoter.Intrasteric inhibition of ATP binding is not required to prevent unregulated autophosphorylation or signaling by the insulin receptor.Insulin and epidermal growth factor suppress basal glucose-6-phosphatase catalytic subunit gene transcription through overlapping but distinct mechanisms.Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.Immunological demonstration of the accumulation of insulin, but not insulin receptors, in nuclei of insulin-treated cells.Agonism and antagonism at the insulin receptor.Functionally distinct insulin receptors generated by tissue-specific alternative splicing.Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.Stat5 is a physiological substrate of the insulin receptor.Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts.Reconstitution of an insulin signaling pathway in Xenopus laevis oocytes: coexpression of a mammalian insulin receptor and three different mammalian hexose transportersEfficient processing and expression of human nerve growth factor receptors in Xenopus laevis oocytes: effects on maturation.Catalysis of serine and tyrosine autophosphorylation by the human insulin receptorIRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors.Proximity measurements between H-2 antigens and the insulin receptor by fluorescence energy transfer: evidence that a close association does not influence insulin binding.Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.CSF-1 receptor/insulin receptor chimera permits CSF-1-dependent differentiation of 3T3-L1 preadipocytes.Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro.Overexpression of integral membrane proteins for structural studies.Characterization of the functional insulin binding epitopes of the full-length insulin receptor.A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.Expression of the insulin receptor with a recombinant vaccinia virus. Biochemical evidence that the insulin receptor has intrinsic serine kinase activity.A consensus insulin response element is activated by an Ets-related transcription factor.Mapping of an NH2-terminal ligand binding site of the insulin receptor by alanine scanning mutagenesis.Complement-induced Ca2+ influx in cultured fibroblasts is decreased by the calcium-channel antagonist nifedipine or by some bivalent inorganic cations.Common and distinct elements in insulin and PDGF signaling.Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cells.Structure and receptor-binding activity of insulin from a holostean fish, the bowfin (Amia calva).Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cellsAnti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA.Concanavalin A-induced receptor aggregation stimulates the tyrosine kinase activity of the insulin receptor in intact cells.Glucose-induced stimulation of human insulin-receptor mRNA and tyrosine kinase activity in cultured cells.Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins.A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin.Non-catalytic activation of phospholipase C-gamma 1 in vitro by epidermal growth factor receptor.Insulin receptor transmembrane signaling: evidence for an intermolecular oligomerization mechanism of activation.
P2860
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P2860
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
description
1987 nî lūn-bûn
@nan
1987 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@ast
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@en
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@nl
type
label
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@ast
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@en
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@nl
prefLabel
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@ast
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@en
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@nl
P2093
P2860
P356
P1476
High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.
@en
P2093
P2860
P304
P356
10.1073/PNAS.84.15.5237
P407
P577
1987-08-01T00:00:00Z