ATPase domain of eukaryotic DNA topoisomerase II. Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization.
about
Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone.ATPases as drug targets: learning from their structure.Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.Single-molecule measurements of the opening and closing of the DNA gate by eukaryotic topoisomerase IIModulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalphaProbing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry.Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism.Analysis of the eukaryotic topoisomerase II DNA gate: a single-molecule FRET and structural perspectiveSynthesis and dissolution of hemicatenanes by type IA DNA topoisomerases.Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II.Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability.Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation.A unique 45-amino-acid region in the toprim domain of Plasmodium falciparum gyrase B is essential for its activity.Characterization of the ATPase activity of topoisomerase II from Leishmania donovani and identification of residues conferring resistance to etoposide.Evidence for the contribution of non-covalent steroid interactions between DNA and topoisomerase in the genotoxicity of steroids.Resveratrol: a novel type of topoisomerase II inhibitor.Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase.Stabilization of protein-protein interactions in drug discovery.Single-molecule Förster resonance energy transfer (FRET) analysis discloses the dynamics of the DNA-topoisomerase II (Top2) interaction in the presence of TOP2-targeting agents.Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform.
P2860
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P2860
ATPase domain of eukaryotic DNA topoisomerase II. Inhibition of ATPase activity by the anti-cancer drug bisdioxopiperazine and ATP/ADP-induced dimerization.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
ATPase domain of eukaryotic DN ...... ATP/ADP-induced dimerization.
@en
ATPase domain of eukaryotic DN ...... ATP/ADP-induced dimerization.
@nl
type
label
ATPase domain of eukaryotic DN ...... ATP/ADP-induced dimerization.
@en
ATPase domain of eukaryotic DN ...... ATP/ADP-induced dimerization.
@nl
prefLabel
ATPase domain of eukaryotic DN ...... ATP/ADP-induced dimerization.
@en
ATPase domain of eukaryotic DN ...... ATP/ADP-induced dimerization.
@nl
P2093
P2860
P356
P1476
ATPase domain of eukaryotic DN ...... ATP/ADP-induced dimerization.
@en
P2093
Harvey Sage
Tao-shih Hsieh
P2860
P304
P356
10.1074/JBC.M111394200
P407
P577
2001-12-07T00:00:00Z