Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.
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SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanismsHead and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde DehydrogenaseASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production.From Krebs to clinic: glutamine metabolism to cancer therapy.Attacking the supply wagons to starve cancer cells to death.Molecular Changes in the Nasal Cavity after N, N-dimethyl-p-toluidine Exposure.Boramino acid as a marker for amino acid transporters.The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1.Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines.Radiosynthesis and preliminary biological evaluation of N-(2-[18F]fluoropropionyl)-L-glutamine as a PET tracer for tumor imaging.Tumour microenvironment factors shaping the cancer metabolism landscape.DNA methylation signatures in peripheral blood strongly predict all-cause mortality.Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulationGlutaminolysis as a target for cancer therapy.ASCT2 regulates glutamine uptake and cell growth in endometrial carcinomaExpression and regulation of drug transporters in vertebrate neutrophils.Glutamine transporters in mammalian cells and their functions in physiology and cancer.Targeting metabolic reprogramming in KRAS-driven cancers.Hypoxia and cellular metabolism in tumour pathophysiology.Targeting amino acid metabolism for cancer therapy.Harnessing Solute Carrier Transporters for Precision Oncology.Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibitionClinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer.Selective amino acid restriction therapy (SAART): a non-pharmacological strategy against all types of cancer cells.Oncogenic regulation of tumor metabolic reprogramming.Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development.Right on TARGET: glutamine metabolism in cancer.mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.Cytotoxicity, Oxidative Stress, Cell Cycle Arrest, and Mitochondrial Apoptosis after Combined Treatment of Hepatocarcinoma Cells with Maleic Anhydride Derivatives and Quercetin.The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate.A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer.Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protein Bcl-xL.Carbon-11 and Fluorine-18 Labeled Amino Acid Tracers for Positron Emission Tomography Imaging of Tumors.Amplifying and broadening the cytotoxic profile of quercetin in cancer cell lines through bioconjugation.Phase IIa clinical study of [18F]fluciclovine: efficacy and safety of a new PET tracer for brain tumors.Amino Acid Metabolism Abnormity and Microenvironment Variation Mediated Targeting and Controlled Glioma Chemotherapy.The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox Code.
P2860
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P2860
Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Amino Acid transporters in can ...... new class of anticancer drugs.
@en
type
label
Amino Acid transporters in can ...... new class of anticancer drugs.
@en
prefLabel
Amino Acid transporters in can ...... new class of anticancer drugs.
@en
P2093
P1433
P1476
Amino Acid transporters in can ...... new class of anticancer drugs.
@en
P2093
Ellappan Babu
Sabarish Ramachandran
Yangzom D Bhutia
P304
P356
10.1158/0008-5472.CAN-14-3745
P407
P577
2015-04-08T00:00:00Z