Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.

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DPP-4 (CD26) inhibitor sitagliptin exerts anti-inflammatory effects on rat insulinoma (RINm) cells via suppressing NF-κB activation.Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation via the coordinated actions of PAQR3 and HUWE1.

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Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.

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2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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Dichotomous role of pancreatic ...... ical and genotoxic conditions.

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Dichotomous role of pancreatic ...... ical and genotoxic conditions.

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Dichotomous role of pancreatic ...... ical and genotoxic conditions.

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P1476

Dichotomous role of pancreatic ...... ical and genotoxic conditions.

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Alannah M Smith

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Cynthia T Luk

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Erica P Cai

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Herbert Gaisano

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Linyuan Wang

http://www.w3.org/2001/XMLSchema#string

Stephanie A Schroer

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Tak W Mak

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Xie Li

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Zhenyue Hao

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P2860

Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones.

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

Ubiquitin ligase ARF-BP1/Mule modulates base excision repair

The ubiquitin ligase COP1 is a critical negative regulator of p53

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

Blinded by the Light: The Growing Complexity of p53

Modes of p53 regulation

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s00125-014-3295-8

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1889-1898

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scholarly article

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10.1007/S00125-014-3295-8

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P E MacDonald

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Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.

about

P2860

P2860

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.

description

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