about
Glucagon secretion and signaling in the development of diabetesOscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitabilitySTEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.Multivesicular exocytosis in rat pancreatic beta cells.Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretionTransplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site.SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells.Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.Human islet function following 20 years of cryogenic biobanking.Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule traffickingGlucose-sensing mechanisms in pancreatic beta-cells.The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and MiceToward Connecting Metabolism to the Exocytotic Site.Impaired "Glycine"-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis.The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.LKB1 couples glucose metabolism to insulin secretion in mice.Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.cAMP-independent effects of GLP-1 on β cells.SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.Metabolomics applied to islet nutrient sensing mechanisms.
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P50
description
researcher
@en
wetenschapper
@nl
name
P E MacDonald
@en
P E MacDonald
@nl
type
label
P E MacDonald
@en
P E MacDonald
@nl
prefLabel
P E MacDonald
@en
P E MacDonald
@nl
P106
P31
P496
0000-0002-5439-6288