Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).
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SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationHeat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetasesRequirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activationGlucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYNT-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domainMechanisms of protein-folding diseases at a glanceContribution of chaperones to STAT pathway signaling.Negative regulation of Lck by Cbl ubiquitin ligaseRegulation of the Src family kinase Lck by Hsp90 and ubiquitinationHsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization.The cellular chaperone heat shock protein 90 facilitates Flock House virus RNA replication in Drosophila cells.HSP90 as a new therapeutic target for cancer therapy: the story unfolds.Structure of an Hsp90-Cdc37-Cdk4 complex.Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy.Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.Retroviral mRNA nuclear export elements regulate protein function and virion assembly.A functional heat shock protein 90 chaperone is essential for efficient flock house virus RNA polymerase synthesis in Drosophila cells.Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.Psychological stress and aging: role of glucocorticoids (GCs)Heat shock protein 90 in plants: molecular mechanisms and roles in stress responses.Impact of heat-shock protein 90 on cancer metastasisHeat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn.A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase.Interaction of activated Cdc42-associated tyrosine kinase ACK2 with HSP90.The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex.How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.PTS2 protein import into mammalian peroxisomes.Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells.Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation.Hsp90 Recognizes a Common Surface on Client Kinases
P2860
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P2860
Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Hsp90 is essential for the syn ...... e, of the Src-kinase p56(lck).
@en
type
label
Hsp90 is essential for the syn ...... e, of the Src-kinase p56(lck).
@en
prefLabel
Hsp90 is essential for the syn ...... e, of the Src-kinase p56(lck).
@en
P2860
P356
P1476
Hsp90 is essential for the syn ...... e, of the Src-kinase p56(lck).
@en
P2093
M J Bijlmakers
P2860
P304
P356
10.1091/MBC.11.5.1585
P50
P577
2000-05-01T00:00:00Z