The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.

The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.

Item
http://www.wikidata.org/entity/Q39948991
k-Nearest neighbor models for microarray gene expression analysis and clinical outcome prediction.Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.The TrkAIII oncoprotein inhibits mitochondrial free radical ROS-induced death of SH-SY5Y neuroblastoma cells by augmenting SOD2 expression and activity at the mitochondria, within the context of a tumour stem cell-like phenotype.TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines.Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases.Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity.TrkAIII promotes microtubule nucleation and assembly at the centrosome in SH-SY5Y neuroblastoma cells, contributing to an undifferentiated anaplastic phenotype.Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation.TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic "Achilles heel" for the TrkAIII oncoprotein in neuroblastoma.TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation.The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII.
P2860

The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.

Item
http://www.wikidata.org/entity/Q39948991
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
The neuroblastoma tumour-suppr ...... in human neuroblastoma cells.
@en
The neuroblastoma tumour-suppr ...... in human neuroblastoma cells.
@nl
type
label
The neuroblastoma tumour-suppr ...... in human neuroblastoma cells.
@en
The neuroblastoma tumour-suppr ...... in human neuroblastoma cells.
@nl
prefLabel
The neuroblastoma tumour-suppr ...... in human neuroblastoma cells.
@en
The neuroblastoma tumour-suppr ...... in human neuroblastoma cells.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P6179
P698
P356
P1433
P1476
The neuroblastoma tumour-suppr ...... in human neuroblastoma cells.
@en
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P6179
P698