Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside.
about
Mitochondria, cholesterol and cancer cell metabolismKilling cancer with platycodin D through multiple mechanismsThe Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila.Antagonism of Bcl-XL is necessary for synergy between carboplatin and BH3 mimetics in ovarian cancer cells.Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling.Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy.Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak.Development of a lytic peptide derived from BH3-only proteinsBcl-xL is an oncogenic driver in colorectal cancer.Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis.Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells.Resistance to Cell Death and Its Modulation in Cancer Stem Cells.Dual targeting of MCL1 and NOXA as effective strategy for treatment of mantle cell lymphoma.Inhibition of Bcl-2 family members sensitizes mesenchymal chondrosarcoma to conventional chemotherapy: report on a novel mesenchymal chondrosarcoma cell line.Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain.Targeting cell death signalling in cancer: minimising 'Collateral damage'.Physiological and Pharmacological Control of BAK, BAX, and Beyond.Therapeutic inhibition of BCL-2 and related family members.Dying to protect: cell death and the control of T-cell homeostasis.Therapeutic implication of concomitant chromosomal aberrations in patients with aggressive B-cell lymphomasApigenin in cancer therapy: anti-cancer effects and mechanisms of action.Curcumin and Melanoma: From Chemistry to Medicine.Caspase cleavage of Mcl-1 impairs its anti-apoptotic activity and proteasomal degradation in non-small lung cancer cells.Selective BCL-XL inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells.The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells.Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.Small molecule inhibitor TW-37 is tolerable and synergistic with chemotherapy in nasopharyngeal carcinoma.
P2860
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P2860
Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Bcl-2 family of proteins as dr ...... imetics from bench to bedside.
@en
type
label
Bcl-2 family of proteins as dr ...... imetics from bench to bedside.
@en
prefLabel
Bcl-2 family of proteins as dr ...... imetics from bench to bedside.
@en
P1476
Bcl-2 family of proteins as dr ...... mimetics from bench to bedside
@en
P2093
Laura Vela
P356
10.1016/J.COPH.2015.05.014
P50
P577
2015-06-14T00:00:00Z