about
TIM polymorphisms--genetics and functionIL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tailThe PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNKT cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation.It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation.Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for TecTIM family proteins and autoimmunity.TIM-1 and TIM-3 proteins in immune regulation.Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis.Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis.Global identification of genes and pathways regulated by Akt during activation of T helper cells.Regulation of NF-κB induction by TCR/CD28.Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion.Galectin-9 regulates T helper cell function independently of Tim-3.Phosphorylation of Carma1, but not Bcl10, by Akt regulates TCR/CD28-mediated NF-κB induction and cytokine production.Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+ T Cell Fate Decisions.Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions.Inhibition of T-cell activation by PIK3IP1.Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.Induction of NF-kappaB by the Akt/PKB kinase.Cellular and biochemical requirements for thymocyte negative selection.The duration of T cell stimulation is a critical determinant of cell fate and plasticity.Murine Tim-1 is excluded from the immunological synapseThrombospondin expression in traumatized skeletal muscle. Correlation of appearance with post-trauma regeneration.Are TIM proteins involved in asthma development or pathology?Intracellular signals that mediate thymic negative selection.Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy.Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin.Antigen receptor kinase two-step.Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion.Immune regulation by Tim-3.TIM3 expression by leukemic and non-leukemic myeloblasts.IL-17 Signaling Triggers Degradation of the Constitutive NF-κB Inhibitor ABIN-1Mast cell activation is enhanced by Tim1:Tim4 interaction but not by Tim-1 antibodiesDifferential Expression of Immune Checkpoint Molecules on CD8+ T Cells Specific for Immunodominant and Subdominant Herpes Simplex Virus 1 Epitopes
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description
hulumtues
@sq
onderzoeker
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researcher
@en
հետազոտող
@hy
name
Lawrence P. Kane
@ast
Lawrence P. Kane
@en
Lawrence P. Kane
@es
Lawrence P. Kane
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type
label
Lawrence P. Kane
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Lawrence P. Kane
@en
Lawrence P. Kane
@es
Lawrence P. Kane
@sl
prefLabel
Lawrence P. Kane
@ast
Lawrence P. Kane
@en
Lawrence P. Kane
@es
Lawrence P. Kane
@sl
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P2798
P31
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0000-0001-5198-516X