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Methods to Increase the Metabolic Stability of (18)F-RadiotracersA Chemical Probe for the ATAD2 BromodomainDirected Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native SubstrateChiral Alkyl Halides: Underexplored Motifs in MedicineDirect synthesis of Z-alkenyl halides through catalytic cross-metathesisContribution of microreactor technology and flow chemistry to the development of green and sustainable synthesisWeak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine DoubleMetal-free C-H alkylation of heteroarenes with alkyltrifluoroborates: a general protocol for 1°, 2° and 3° alkylation.Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach.Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.Kinetically controlled E-selective catalytic olefin metathesis.Targeting Steroidogenic Cytochromes P450 (CYPs) with 6-Substituted 1-Imidazolylmethylxanthones.Free Radical Chemistry Enabled by Visible Light-Induced Electron Transfer.Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.In-Depth Assessment of the Palladium-Catalyzed Fluorination of Five-Membered Heteroaryl Bromides.A two-step approach to achieve secondary amide transamidation enabled by nickel catalysis.Catalytic enantioselective addition of organoboron reagents to fluoroketones controlled by electrostatic interactions.Late Stage Azidation of Complex Molecules.Rapid cycloaddition of a diazo group with an unstrained dipolarophile.Phytoalexin Phenalenone Derivatives Inactivate Mosquito Larvae and Root-knot Nematode as Type-II Photosensitizer.Sodium fluoride (NaF) causes toxic effects on splenic development in mice.Multigram-scale Synthesis of Enantiopure 3,3-Difluoroproline.Fluorine-18 patents (2009-2015). Part 1: novel radiotracers.Novel Sulfamide-Containing Compounds as Selective Carbonic Anhydrase I Inhibitors.Fluorinated cyclometalated iridium(iii) complexes as mitochondria-targeted theranostic anticancer agents.Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines.Design, synthesis, and biological evaluation of 1,9-diheteroarylnona-1,3,6,8-tetraen-5-ones as a new class of anti-prostate cancer agents.Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions.Hypervalent iodine(iii) fluorinations of alkenes and diazo compounds: new opportunities in fluorination chemistry.Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.The unique fluorine effects in organic reactions: recent facts and insights into fluoroalkylations.Fluorine-18 patents (2009-2015). Part 2: new radiochemistry.Recent Advances in the Synthesis of SCF2 H- and SCF2 FG-Containing Molecules.Recent Progress Toward the Synthesis of Trifluoromethyl- and Difluoromethyl-Substituted Cyclopropanes.Bioactive Natural Product and Superacid Chemistry for Lead Compound Identification: A Case Study of Selective hCA III and L-Type Ca2+ Current Inhibitors for Hypotensive Agent Discovery.Stereoretentive Olefin Metathesis: An Avenue to Kinetic Selectivity.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Applications of Fluorine in Medicinal Chemistry.
@en
type
label
Applications of Fluorine in Medicinal Chemistry.
@en
prefLabel
Applications of Fluorine in Medicinal Chemistry.
@en
P2093
P1476
Applications of Fluorine in Medicinal Chemistry.
@en
P2093
David J Donnelly
Eric P Gillis
Kyle J Eastman
Matthew D Hill
Nicholas A Meanwell
P304
P356
10.1021/ACS.JMEDCHEM.5B00258
P407
P577
2015-07-22T00:00:00Z