Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein.
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Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosisFiloviral immune evasion mechanismsMutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcomeEbola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola VirusEbolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppressionStructure of the Ebola VP35 interferon inhibitory domainMutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea PigsStructural basis for dsRNA recognition and interferon antagonism by Ebola VP35Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory DomainEbola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machineryEbolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling.Comparative pathogenesis and systems biology for biodefense virus vaccine development.Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica.Ebola virus modulates transforming growth factor β signaling and cellular markers of mesenchyme-like transition in hepatocytes.Interplay between innate immunity and negative-strand RNA viruses: towards a rational modelHow Ebola virus counters the interferon system.Camouflage and misdirection: the full-on assault of ebola virus diseaseA systems biology starter kit for arenaviruses.Ebolavirus VP35 is a multifunctional virulence factor.Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.Virus-like particles activate type I interferon pathways to facilitate post-exposure protection against Ebola virus infection.Functional genomics reveals the induction of inflammatory response and metalloproteinase gene expression during lethal Ebola virus infection.The role of antigen-presenting cells in filoviral hemorrhagic fever: gaps in current knowledge.Applications of high-throughput genomics to antiviral research: evasion of antiviral responses and activation of inflammation during fulminant RNA virus infection.Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains.Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.The C proteins of human parainfluenza virus type 1 (HPIV1) control the transcription of a broad array of cellular genes that would otherwise respond to HPIV1 infectionEbolavirus VP35 interacts with the cytoplasmic dynein light chain 8In vivo Ebola virus infection leads to a strong innate response in circulating immune cells.Ebola virus VP35 antagonizes PKR activity through its C-terminal interferon inhibitory domain.Evasion of interferon responses by Ebola and Marburg viruses.Vaccine and adjuvant design for emerging viruses: mutations, deletions, segments and signaling.Activation of the Antiviral Kinase PKR and Viral Countermeasures.Correlates of immunity to filovirus infection.Systems kinomics for characterizing host responses to high-consequence pathogens at the NIH/NIAID Integrated Research Facility-Frederick.Viral proteins that bind double-stranded RNA: countermeasures against host antiviral responses.Potential biomarkers and latent pathways for vasculitis based on latent pathway identification analysis.
P2860
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P2860
Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Whole-genome expression profil ...... id change in the VP35 protein.
@en
type
label
Whole-genome expression profil ...... id change in the VP35 protein.
@en
prefLabel
Whole-genome expression profil ...... id change in the VP35 protein.
@en
P2860
P50
P356
P1433
P1476
Whole-genome expression profil ...... id change in the VP35 protein.
@en
P2093
P2860
P304
P356
10.1128/JVI.00215-08
P407
P577
2008-03-19T00:00:00Z