Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions.
about
Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptorPhotochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation.How theories evolved concerning the mechanism of action of barbiturates.A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.Structural link between γ-aminobutyric acid type A (GABAA) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulationAgonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor.Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel.A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics.Disrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited statesDistinct structural changes in the GABAA receptor elicited by pentobarbital and GABA.The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists.Insights into the structure and pharmacology of GABA(A) receptors.Probing pore constriction in a ligand-gated ion channel by trapping a metal ion in the pore upon agonist dissociation.Activation of alpha6-containing GABAA receptors by pentobarbital occurs through a different mechanism than activation by GABA.Phenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function.
P2860
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P2860
Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Gamma-aminobutyric acid (GABA) ...... pha1 and beta2 pre-M1 regions.
@en
type
label
Gamma-aminobutyric acid (GABA) ...... pha1 and beta2 pre-M1 regions.
@en
prefLabel
Gamma-aminobutyric acid (GABA) ...... pha1 and beta2 pre-M1 regions.
@en
P2860
P356
P1476
Gamma-aminobutyric acid (GABA) ...... pha1 and beta2 pre-M1 regions.
@en
P2093
Cynthia Czajkowski
Jose Mercado
P2860
P304
15250-15257
P356
10.1074/JBC.M708638200
P407
P577
2008-04-03T00:00:00Z