Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.
about
Mechanistic insights into mode of action of novel natural cathepsin L inhibitors.Structure-antiproliferative activity studies on l-proline- and homoproline-4-N-pyrrolidine-3-thiosemicarbazone hybrids and their nickel(ii), palladium(ii) and copper(ii) complexes.Copper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells.Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) induces apoptosis in ovarian cancer cells.Phase II trial of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehydethiosemicarbazone plus gemcitabine in patients with advanced biliary tract cancerPhase I Trial of Triapine-Cisplatin-Paclitaxel Chemotherapy for Advanced Stage or Metastatic Solid Tumor Cancers.Ribonucleotide reductase metallocofactor: assembly, maintenance and inhibition.Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance.Nucleotide metabolism, oncogene-induced senescence and cancer.Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors.A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo.Population pharmacokinetics of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (Triapine®) in cancer patients.A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas.Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents.Crystal structures of two hydrazinecarbo-thio-amide derivatives: (E)-N-ethyl-2-[(4-oxo-4H-chromen-3-yl)methyl-idene]hydrazinecarbo-thio-amide hemi-hydrate and (E)-2-[(4-chloro-2H-chromen-3-yl)methyl-idene]-N-phenyl-hydrazinecarbo-thio-amide.Determination of triapine, a ribonucleotide reductase inhibitor, in human plasma by liquid chromatography tandem mass spectrometry.Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.Crystal structure of [(E)-({2-[3-(2-{(1E)-[(carbamo-thioyl-amino)-imino]-meth-yl}phen-oxy)prop-oxy]phen-yl}methyl-idene)amino]-thio-urea with an unknown solvateAtaxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasisPAN-811 Blocks Chemotherapy Drug-Induced In Vitro Neurotoxicity, While Not Affecting Suppression of Cancer Cell GrowthMechanistic studies of semicarbazone triapine targeting human ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species.Cell permeable iron chelators as potential cancer chemotherapeutic agents.Neuroprotective activity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (PAN-811), a cancer therapeutic agent.Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes.Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trappingTriapine potentiates platinum-based combination therapy by disruption of homologous recombination repair.Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.Identification of compounds selectively killing multidrug-resistant cancer cellsIdentification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancerTriapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors.Anticancer activity of metal complexes: involvement of redox processes.Thiosemicarbazones: the new wave in cancer treatment.Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.Metabolic alterations accompanying oncogene-induced senescence.ATM couples replication stress and metabolic reprogramming during cellular senescence.New palladium and platinum complexes with bioactive 3,5-diacetyl-1,2,4-triazol bis(4-cyclohexyl thiosemicarbazone) ligand: chemistry, antiproliferative activity and preliminary toxicity studies.Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds.Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): a combined experimental and theoretical study.Novel bis(thiosemicarbazones) of the 3,5-diacetyl-1,2,4-triazol series and their platinum(II) complexes: chemistry, antiproliferative activity and preliminary nephrotoxicity studies.
P2860
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P2860
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Triapine (3-aminopyridine-2-ca ...... with antineoplastic activity.
@ast
Triapine (3-aminopyridine-2-ca ...... with antineoplastic activity.
@en
type
label
Triapine (3-aminopyridine-2-ca ...... with antineoplastic activity.
@ast
Triapine (3-aminopyridine-2-ca ...... with antineoplastic activity.
@en
prefLabel
Triapine (3-aminopyridine-2-ca ...... with antineoplastic activity.
@ast
Triapine (3-aminopyridine-2-ca ...... with antineoplastic activity.
@en
P2093
P1476
Triapine (3-aminopyridine-2-ca ...... with antineoplastic activity.
@en
P2093
P356
10.1016/S0065-2571(98)00017-X
P577
1999-01-01T00:00:00Z