Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.
about
The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.Discovery of new GPCR ligands to illuminate new biology.Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats.
P2860
Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Novel Agonist Bioisosteres and ...... otein-Coupled Receptor GPR139.
@en
type
label
Novel Agonist Bioisosteres and ...... otein-Coupled Receptor GPR139.
@en
prefLabel
Novel Agonist Bioisosteres and ...... otein-Coupled Receptor GPR139.
@en
P2093
P2860
P50
P356
P1433
P1476
Novel Agonist Bioisosteres and ...... otein-Coupled Receptor GPR139.
@en
P2093
Anne C Nøhr
Delphine Lissa
Kirsten B Andersen
Vignir Isberg
P2860
P2888
P356
10.1038/SREP36681
P407
P577
2016-11-10T00:00:00Z
P6179
1032653141