Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei.
about
Identification of attractive drug targets in neglected-disease pathogens using an in silico approachKinases as druggable targets in trypanosomatid protozoan parasitesRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisStructural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamicsStructure analysis of Entamoeba histolytica enolaseThe Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine SiteStructural role of the active-site metal in the conformation of Trypanosoma brucei phosphoglycerate mutase`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinaseTargeting pathogen metabolism without collateral damage to the hostA target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activityNaphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanismWhat can we learn from global sensitivity analysis of biochemical systems?Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma bruceiRibose 5-phosphate isomerase B knockdown compromises Trypanosoma brucei bloodstream form infectivityStructures of pyruvate kinases display evolutionarily divergent allosteric strategiesDynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolismRewiring and regulation of cross-compartmentalized metabolism in protistsProteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi.Dynamic analysis of integrated signaling, metabolic, and regulatory networks.TIde: a software for the systematic scanning of drug targets in kinetic network models.Exocytosis and protein secretion in Trypanosoma.Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase.Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source.A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway.Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent.A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1.Systems biology: the next frontier for bioinformatics.Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomesEnolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites-perspectives for its use as a therapeutic target.An online model composition tool for system biology models.Determining enzyme kinetics for systems biology with nuclear magnetic resonance spectroscopy.Evidence for loss of a partial flagellar glycolytic pathway during trypanosomatid evolutionGlycerol 3-phosphate alters Trypanosoma brucei hexokinase activity in response to environmental changeGlycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic developmentAssembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme.The return of metabolism: biochemistry and physiology of the pentose phosphate pathwaySystems biology from micro-organisms to human metabolic diseases: the role of detailed kinetic models.Conservation of PEX19-binding motifs required for protein targeting to mammalian peroxisomal and trypanosome glycosomal membranesLC-MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes.
P2860
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P2860
Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Experimental and in silico ana ...... tream form Trypanosoma brucei.
@en
type
label
Experimental and in silico ana ...... tream form Trypanosoma brucei.
@en
prefLabel
Experimental and in silico ana ...... tream form Trypanosoma brucei.
@en
P2093
P2860
P50
P356
P1476
Experimental and in silico ana ...... tream form Trypanosoma brucei.
@en
P2093
Joris Van Roy
Marie-Astrid Albert
Paul A M Michels
Véronique Hannaert
P2860
P304
28306-28315
P356
10.1074/JBC.M502403200
P407
P577
2005-06-14T00:00:00Z