A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity
about
Identification of attractive drug targets in neglected-disease pathogens using an in silico approachKinases as druggable targets in trypanosomatid protozoan parasitesIdentification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaignSequence analysis and molecular characterization of Clonorchis sinensis hexokinase, an unusual trimeric 50-kDa glucose-6-phosphate-sensitive allosteric enzymeAdvanced enzymology, expression profile and immune response of Clonorchis sinensis hexokinase show its application potential for prevention and control of clonorchiasisPrecursor-Directed Combinatorial Biosynthesis of Cinnamoyl, Dihydrocinnamoyl, and Benzoyl Anthranilates in Saccharomyces cerevisiaeAntiparasitic lethality of sulfonamidebenzamides in kinetoplastids.Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1.Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase.Chemical genomics for studying parasite gene function and interaction.Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic developmentThree-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Trypanosoma brucei: inhibition of acetyl-CoA carboxylase by haloxyfopStructure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase.An alternative in vitro drug screening test using Leishmania amazonensis transfected with red fluorescent protein.Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition.Development of novel drugs for human African trypanosomiasis.Translocation of solutes and proteins across the glycosomal membrane of trypanosomes; possibilities and limitations for targeting with trypanocidal drugs.In silico search of energy metabolism inhibitors for alternative leishmaniasis treatments.Evaluation of substituted ebselen derivatives as potential trypanocidal agents.Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.A targeted delivery strategy for the development of potent trypanocides.
P2860
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P2860
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A target-based high throughput ...... rs with antiparasitic activity
@ast
A target-based high throughput ...... rs with antiparasitic activity
@en
A target-based high throughput ...... rs with antiparasitic activity
@nl
type
label
A target-based high throughput ...... rs with antiparasitic activity
@ast
A target-based high throughput ...... rs with antiparasitic activity
@en
A target-based high throughput ...... rs with antiparasitic activity
@nl
prefLabel
A target-based high throughput ...... rs with antiparasitic activity
@ast
A target-based high throughput ...... rs with antiparasitic activity
@en
A target-based high throughput ...... rs with antiparasitic activity
@nl
P2093
P2860
P921
P1476
A target-based high throughput ...... rs with antiparasitic activity
@en
P2093
David Close
Gabriela Mustata
Heidi C Dodson
James C Morris
Kuo-Hsiung Lee
Meredith T Morris
Stephanie S Leimgruber
Todd A Lyda
Yoshiki Kashiwada
P2860
P356
10.1371/JOURNAL.PNTD.0000659
P407
P577
2010-04-13T00:00:00Z