Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.
about
The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channelsEpithelial Anion Transport as Modulator of Chemokine SignalingNovel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway DiseasesHigh throughput screening technologies for ion channelsA synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cellsAntagonists of the TMEM16A calcium-activated chloride channel modulate airway smooth muscle tone and intracellular calcium.A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipidAirway Gland Structure and FunctionFractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16AAntidiarrheal efficacy and cellular mechanisms of a Thai herbal remedyInhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cellsInhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell LinesAni9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blockerVariomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation.Anoctamin-1 Cl(-) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesisLuminally Acting Agents for Constipation Treatment: A Review Based on Literatures and Patents.Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.CFTR inhibitors.Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion.Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonistPresynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina.Microfluidics platform for single-shot dose-response analysis of chloride channel-modulating compoundsMolecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.Two helices in the third intracellular loop determine anoctamin 1 (TMEM16A) activation by calciumEffects of new-generation inhibitors of the calcium-activated chloride channel anoctamin 1 on slow waves in the gastrointestinal tract.Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.Modulation of Chloride Channel Functions by the Plant Lignan Compounds Kobusin and Eudesmin.Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contractionProinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia.Control of TMEM16A by INO-4995 and other inositolphosphates.Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01The molecular basis of the genesis of basal tone in internal anal sphincter.The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion.Eact, a small molecule activator of TMEM16A, activates TRPV1 and elicits pain- and itch-related behaviours.Role of Quercetin in Modulating Chloride Transport in the Intestine.Chloride channel-targeted therapy for secretory diarrheasCl⁻ channels in smooth muscle cells.Ca2+-activated Cl- channels at a glance.
P2860
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P2860
Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Small-molecule activators of T ...... on and intestinal contraction.
@en
type
label
Small-molecule activators of T ...... on and intestinal contraction.
@en
prefLabel
Small-molecule activators of T ...... on and intestinal contraction.
@en
P2093
P2860
P356
P1433
P1476
Small-molecule activators of T ...... on and intestinal contraction.
@en
P2093
A S Verkman
Walter E Finkbeiner
Wan Namkung
P2860
P304
P356
10.1096/FJ.11-191627
P407
P577
2011-08-11T00:00:00Z