Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan - Wikidata - wikimedia - TriplyDB

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

http://www.wikidata.org/entity/Q38927275

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Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Quantification and expert evaluation of evidence for chemopredictive biomarkers to personalize cancer treatment.Topoisomerase I copy number alterations as biomarker for irinotecan efficacy in metastatic colorectal cancer.Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1 Targeting of topoisomerases for prognosis and drug resistance in ovarian cancer.Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.Targeted Proteomics for Multiplexed Verification of Markers of Colorectal Tumorigenesis.Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria.Drug resistance and new therapies in colorectal cancer

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P2860

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

http://www.wikidata.org/entity/Q38927275

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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Clinical and cellular roles fo ...... cancer response to irinotecan

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Clinical and cellular roles fo ...... cancer response to irinotecan

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Clinical and cellular roles fo ...... cancer response to irinotecan

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1535-7163.MCT-14-0762

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Molecular Cancer Therapeutics

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Clinical and cellular roles fo ...... cancer response to irinotecan

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P2093

Anthony Chalmers

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Cornelia Meisenberg

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Sherif F El-Khamisy

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Simon Gollins

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Vikki Haley

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P2860

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

A model for the mechanism of human topoisomerase I

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells

TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

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575-585

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10.1158/1535-7163.MCT-14-0762

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2

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14

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Duncan C Gilbert

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2014-12-18T00:00:00Z

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25522766

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colorectal cancer

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4340569

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