TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
about
A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damageFunctional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulationOptimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PKPP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues.R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxiasAnalysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D SuperfamilyTyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Processing of damaged DNA ends for double-strand break repair in mammalian cellsTDP2 protects transcription from abortive topoisomerase activity and is required for normal neural functionThe genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionMitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria.In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutationThe DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromesMutant huntingtin impairs Ku70-mediated DNA repair.SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitorsThiopurine methyltransferase predicts the extent of cytotoxicty and DNA damage in astroglial cells after thioguanine exposure.DNA repair deficiency in neurodegeneration.Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break.Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).Neurological disorders associated with DNA strand-break processing enzymes.DNA repair mechanisms in dividing and non-dividing cells.Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitorsThe role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.Disconnecting XRCC1 and DNA ligase IIITyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemiaTDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions.Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis.The involvement of DNA-damage and -repair defects in neurological dysfunctionDNA damage and repair: relevance to mechanisms of neurodegenerationBrain capacity for repair of oxidatively damaged DNA and preservation of neuronal function.
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P2860
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo
description
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
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im November 2007 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2007/11/14)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/11/14)
@nl
наукова стаття, опублікована в листопаді 2007
@uk
مقالة علمية (نشرت في 14-11-2007)
@ar
name
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@ast
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@en
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@nl
type
label
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@ast
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@en
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@nl
prefLabel
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@ast
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@en
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@nl
P2093
P2860
P356
P1433
P1476
TDP1 facilitates chromosomal s ...... and is neuroprotective in vivo
@en
P2093
Helen R Russell
Keith W Caldecott
Peter J McKinnon
Sherif F el-Khamisy
P2860
P304
P356
10.1038/SJ.EMBOJ.7601869
P407
P577
2007-10-04T00:00:00Z