SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.
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Histone H3 mutations--a special role for H3.3 in tumorigenesis?SETD2: an epigenetic modifier with tumor suppressor functionalityThe roles of chromatin-remodelers and epigenetic modifiers in kidney cancerIncreased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinomaGenomic aberrations frequently alter chromatin regulatory genes in chordoma.Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.DNA double-strand break repair: a tale of pathway choices.Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma.Genomic alterations in DNA repair and chromatin remodeling genes in estrogen receptor-positive metastatic breast cancer patients with exceptional responses to capecitabine.DNA double strand break repair pathway choice: a chromatin based decision?Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity.SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2.New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease.Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model.Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell CarcinomaGenomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme.Selective suppression of antisense transcription by Set2-mediated H3K36 methylationSPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma.In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites.Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma.BAP1, PBRM1 and SETD2 in clear-cell renal cell carcinoma: molecular diagnostics and possible targets for personalized therapies.Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation.SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis.Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair.Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes.Marked for death: targeting epigenetic changes in cancer.Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 TrimethylationDual Chromatin and Cytoskeletal Remodeling by SETD2.Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage.The nucleosome: orchestrating DNA damage signaling and repair within chromatin.Precision medicine from the renal cancer genome.Oncogenic Mechanisms of Histone H3 Mutations.The epigenetic landscape of renal cancer.Multifunctional Involvement of a C2H2 Zinc Finger Protein (PbZfp) in Malaria Transmission, Histone Modification, and Susceptibility to DNA Damage Response
P2860
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P2860
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
SETD2 is required for DNA doub ...... f the p53-mediated checkpoint.
@en
type
label
SETD2 is required for DNA doub ...... f the p53-mediated checkpoint.
@en
prefLabel
SETD2 is required for DNA doub ...... f the p53-mediated checkpoint.
@en
P2093
P2860
P50
P356
P1433
P1476
SETD2 is required for DNA doub ...... of the p53-mediated checkpoint
@en
P2093
Ana C Raposo
Filipa B Martins
João Ferreira
Sreerama C Sridhara
P2860
P304
P356
10.7554/ELIFE.02482
P407
P577
2014-05-06T00:00:00Z