Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
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Targeting the Pim kinases in multiple myelomaNew investigational drugs with single-agent activity in multiple myelomaA small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomasTargeting Pim kinases for cancer treatment: opportunities and challengesCharacterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancerTargeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subsetPIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.Computational prediction and experimental validation of a novel synthesized pan-PIM inhibitor PI003 and its apoptosis-inducing mechanisms in cervical cancer.Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia.Control of Pim2 kinase stability and expression in transformed human haematopoietic cellsThe PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells.Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors.FLT3 inhibitors: clinical potential in acute myeloid leukemia.PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.Kinase inhibitors as potential agents in the treatment of multiple myeloma.Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias.Pim kinases in hematological malignancies: where are we now and where are we going?Targeted therapy of acute myeloid leukemia.PIM kinase (and Akt) biology and signaling in tumors.Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket.Synthesis of new pyridothienopyrimidinone derivatives as Pim-1 inhibitors.PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.Elevated PIM2 gene expression is associated with poor survival of patients with acute myeloid leukemia.Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks.Pim2 is important for regulating DNA damage response in multiple myeloma cells.Novel inhibition of PIM2 kinase has significant anti-tumor efficacy in multiple myeloma.Insulin receptor substrate 1 is a substrate of the Pim protein kinases.The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing.Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447.Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia.Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole.Acute myeloid leukaemia.RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia.Pim Kinase Inhibitors Evaluated with a Single-Molecule Engineered Nanopore Sensor.Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer.Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.Downregulation of PIM1 regulates glycolysis and suppresses tumor progression in gallbladder cancer
P2860
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P2860
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
@en
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
@nl
type
label
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
@en
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
@nl
prefLabel
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
@en
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
@nl
P2093
P1476
Pan-PIM kinase inhibition provides a novel therapy for treating hematologic cancers.
@en
P2093
Audrey Kauffmann
Christie Fanton
Christine Fritsch
Christopher Wilson
Cornelia Bellamacina
Estelle Pfister
Gisele Nishiguchi
J Alex Aycinena
Jamie Narberes
Jianjun Yu
P304
P356
10.1158/1078-0432.CCR-13-2062
P407
P577
2014-01-28T00:00:00Z