APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. - Wikidata - wikimedia - TriplyDB

APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction.

APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction.

http://www.wikidata.org/entity/Q39127701

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The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5 Emerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3τ interaction domain with a canonical G-protein interaction site The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons.APPL proteins FRET at the BAR: direct observation of APPL1 and APPL2 BAR domain-mediated interactions on cell membranes using FRET microscopy Impairment of TrkB-PSD-95 signaling in Angelman syndrome High-resolution fractionation of signaling endosomes containing different receptors Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes Endocytosis and signalling: intertwining molecular networks The neurotrophin receptor signaling endosome: Where trafficking meets signaling.Endocytosis and endosomes at the crossroads of regulating trafficking of axon outgrowth-modifying receptors.Functional proteomics, human genetics and cancer biology of GIPC family members Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and Disease Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts An inside view: VEGF receptor trafficking and signaling Identification of phosphorylation sites within the signaling adaptor APPL1 by mass spectrometry.Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2.Cdo interacts with APPL1 and activates Akt in myoblast differentiation.Autocrine VEGF signaling is required for vascular homeostasis.The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway ESCRT-0 marks an APPL1-independent transit route for EGFR between the cell surface and the EEA1-positive early endosome.Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling.GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice.Genome-wide methylation profiling of schizophrenia.NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib.The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function.Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.Multifunctional protein APPL2 contributes to survival of human glioma cells.Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury.

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APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction.

http://www.wikidata.org/entity/Q39127701

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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name

APPL1 associates with TrkA and ...... -mediated signal transduction.

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APPL1 associates with TrkA and ...... -mediated signal transduction.

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type

label

APPL1 associates with TrkA and ...... -mediated signal transduction.

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APPL1 associates with TrkA and ...... -mediated signal transduction.

@nl

prefLabel

APPL1 associates with TrkA and ...... -mediated signal transduction.

@en

APPL1 associates with TrkA and ...... -mediated signal transduction.

@nl

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Molecular and Cellular Biology

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APPL1 associates with TrkA and ...... -mediated signal transduction.

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P2093

Alex Bell

http://www.w3.org/2001/XMLSchema#string

Celia Quevedo

http://www.w3.org/2001/XMLSchema#string

Dan C Lin

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David R Kaplan

http://www.w3.org/2001/XMLSchema#string

Freda D Miller

http://www.w3.org/2001/XMLSchema#string

Joseph R Testa

http://www.w3.org/2001/XMLSchema#string

Mark L Grimes

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Natalie E Brewer

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P2860

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

Myo6 facilitates the translocation of endocytic vesicles from cell peripheries

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways

Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton

Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics

Rab proteins as membrane organizers

Neurotrophin signal transduction in the nervous system.

GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function

Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors

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8928-8941

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10.1128/MCB.00228-06

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23

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26

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2006-09-25T00:00:00Z

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17000777

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1636815

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