Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts
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Phosphoinositides: Key modulators of energy metabolismAppl1 is dispensable for Akt signaling in vivo and mouse T-cell developmentAbsence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomesAn APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neuronsThe adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilizationRab31 and APPL2 enhance FcγR-mediated phagocytosis through PI3K/Akt signaling in macrophagesAPPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis.Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling.The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and SensitivityEvidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.Multifunctional protein APPL2 contributes to survival of human glioma cells.APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain.Expression of APPL1 is correlated with clinicopathologic characteristics and poor prognosis in patients with gastric cancer.Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells.The role of adiponectin signaling in metabolic syndrome and cancer.Role of Rab GTPases and their interacting proteins in mediating metabolic signalling and regulation.APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes.APPL1 is a multifunctional endosomal signaling adaptor protein.APPL1 regulates basal NF-κB activity by stabilizing NIK.Serum starvation: caveat emptor.Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma.α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration.Intranasal administration of recombinant Netrin-1 attenuates neuronal apoptosis by activating DCC/APPL-1/AKT signaling pathway after subarachnoid hemorrhage in rats.The Role of PI3K in Met Driven Cancer: A Recap
P2860
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P2860
Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Appl1 is dispensable for mouse ...... n murine embryonic fibroblasts
@ast
Appl1 is dispensable for mouse ...... n murine embryonic fibroblasts
@en
type
label
Appl1 is dispensable for mouse ...... n murine embryonic fibroblasts
@ast
Appl1 is dispensable for mouse ...... n murine embryonic fibroblasts
@en
prefLabel
Appl1 is dispensable for mouse ...... n murine embryonic fibroblasts
@ast
Appl1 is dispensable for mouse ...... n murine embryonic fibroblasts
@en
P2093
P2860
P356
P1476
Appl1 is dispensable for mouse ...... n murine embryonic fibroblasts
@en
P2093
Deborah A Altomare
Huihong You
Joseph R Testa
Yinfei Tan
P2860
P304
P356
10.1074/JBC.M109.068452
P407
P577
2009-12-29T00:00:00Z