about
Identification of conformationally sensitive residues essential for inhibition of vesicular monoamine transport by the noncompetitive inhibitor tetrabenazineFunctional analysis of novel multidrug transporters from human pathogensA Transporter Interactome Is Essential for the Acquisition of Antimicrobial Resistance to AntibioticsDirected evolution reveals hidden properties of VMAT, a neurotransmitter transporterProjection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 A resolutionA common binding site for substrates and protons in EmrE, an ion-coupled multidrug transporter.Expression of neurotransmitter transporters for structural and biochemical studiesThree-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer.Histidine-226 is part of the pH sensor of NhaA, a Na+/H+ antiporter in Escherichia coli.The projection structure of EmrE, a proton-linked multidrug transporter from Escherichia coli, at 7 A resolutionUndecided membrane proteins insert in random topologies. Up, down and sideways: it does not really matterThe fast release of sticky protons: kinetics of substrate binding and proton release in a multidrug transporterIn vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric stateNa+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinizationNew substrates on the block: clinically relevant resistances for EmrE and homologues.When biochemistry meets structural biology: the cautionary tale of EmrE.A coordinated network of transporters with overlapping specificities provides a robust survival strategy.EmrE, a model for studying evolution and mechanism of ion-coupled transporters.Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis.Sodium-proton antiport in isolated membrane vesicles of Escherichia coli.Proton electrochemical gradient in Escherichia coli cells and its relation to active transport of lactose.The role of a transmembrane pH gradient in 5-hydroxy tryptamine uptake by synaptic vesicles from rat brain.Identification of a glycine motif required for packing in EmrE, a multidrug transporter from Escherichia coli.Solubilization and reconstitution of the catecholamine transporter from bovine chromaffin granules.The amine transporter from bovine chromaffin granules.Intracellular pH and membrane potential as regulators in the prokaryotic cell.Membrane potential and active transport in membrane vesicles from Escherichia coli.Expression and function of the rat vesicular monoamine transporter 2.pH homeostasis in bacteria.Molecular biology of Na+/H+ antiporters: molecular devices that couple the Na+ and H+ circulation in cells.Molecular physiology of Na+/H+ antiporters, key transporters in circulation of Na+ and H+ in cells.Reconstitution of LAC carrier function in cholate-extracted membranes from Escherichia coli.The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters.Reserpine as a competitive and reversible inhibitor of the catecholamine transporter of bovine chromaffin granules.Specificity determinants in small multidrug transporters.Energetics of reserpine binding and occlusion by the chromaffin granule biogenic amine transporter.The amine transporter from bovine chromaffin granules: photolabeling and partial purification.Cloning, sequencing and expression of the nhaA and nhaR genes from Salmonella enteritidis.An essential glutamyl residue in EmrE, a multidrug antiporter from Escherichia coli.A model for coupling of H(+) and substrate fluxes based on "time-sharing" of a common binding site.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Schuldiner S
@ast
Schuldiner S
@es
Schuldiner S
@nl
Schuldiner S
@sl
Shimon Schuldiner
@en
type
label
Schuldiner S
@ast
Schuldiner S
@es
Schuldiner S
@nl
Schuldiner S
@sl
Shimon Schuldiner
@en
altLabel
Schuldiner S
@en
prefLabel
Schuldiner S
@ast
Schuldiner S
@es
Schuldiner S
@nl
Schuldiner S
@sl
Shimon Schuldiner
@en
P1053
F-7628-2012
P106
P31
P496
0000-0002-4874-6237