Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity. - Wikidata - wikimedia - TriplyDB

Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity.

Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity.

http://www.wikidata.org/entity/Q39192241

about

Clinical significance of T cell metabolic reprogramming in cancer Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication Broad targeting of angiogenesis for cancer prevention and therapy Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma.T cell metabolic fitness in antitumor immunity.Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.Metformin inhibits gastric cancer via the inhibition of HIF1α/PKM2 signaling Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy.Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?Lactate, a Neglected Factor for Diabetes and Cancer Interaction.Dichloroacetate modulates cytokines toward T helper 1 function via induction of the interleukin-12-interferon-γ pathway.Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells.Extracellular acidity, a "reappreciated" trait of tumor environment driving malignancy: perspectives in diagnosis and therapy.Metabolism of stromal and immune cells in health and disease.Taming Tumor Glycolysis and Potential Implications for Immunotherapy.The acidic microenvironment as a possible niche of dormant tumor cells.The role of metabolic reprogramming in T cell fate and function.Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.Tumor cells and memory T cells converge at glycolysis: therapeutic implications.M2-like macrophage polarization in high lactic acid-producing head and neck cancer Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer.Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity.The spectrum of T cell metabolism in health and disease.Regulation of Immune Cell Functions by Metabolic Reprogramming.Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy

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Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity.

http://www.wikidata.org/entity/Q39192241

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Dichloroacetate improves immun ...... es antitumor immunoreactivity.

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Dichloroacetate improves immun ...... es antitumor immunoreactivity.

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type

label

Dichloroacetate improves immun ...... es antitumor immunoreactivity.

@en

Dichloroacetate improves immun ...... es antitumor immunoreactivity.

@nl

prefLabel

Dichloroacetate improves immun ...... es antitumor immunoreactivity.

@en

Dichloroacetate improves immun ...... es antitumor immunoreactivity.

@nl

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International Journal of Cancer

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Dichloroacetate improves immun ...... es antitumor immunoreactivity.

@en

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Bunya Kuze

http://www.w3.org/2001/XMLSchema#string

Keisuke Mizuta

http://www.w3.org/2001/XMLSchema#string

Mitsuhiro Aoki

http://www.w3.org/2001/XMLSchema#string

Norimitsu Inoue

http://www.w3.org/2001/XMLSchema#string

Takashi Akazawa

http://www.w3.org/2001/XMLSchema#string

Toshimitsu Ohashi

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Yatsuji Ito

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P2860

Clinical pharmacology and toxicology of dichloroacetate

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Cancer-related inflammation

Immunity, Inflammation, and Cancer

Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children

IL-23 promotes tumour incidence and growth

Metabolic modulation of glioblastoma with dichloroacetate

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

Why do cancers have high aerobic glycolysis?

Regulation of cancer cell metabolism

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scholarly article

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10.1002/IJC.28114

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5

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133

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2013-03-16T00:00:00Z

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235659201

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23420584

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dichloroacetate