Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins.
about
Chemical inhibition of NAT10 corrects defects of laminopathic cells.Aging and HIV/AIDS: pathogenetic role of therapeutic side effectsA mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorderSulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.Prelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.Progerin expression disrupts critical adult stem cell functions involved in tissue repair.Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts.Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient
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Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins.
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name
Blocking farnesylation of the ...... distribution of A-type lamins.
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Blocking farnesylation of the ...... distribution of A-type lamins.
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Blocking farnesylation of the ...... distribution of A-type lamins.
@en
Blocking farnesylation of the ...... distribution of A-type lamins.
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Blocking farnesylation of the ...... distribution of A-type lamins.
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Blocking farnesylation of the ...... distribution of A-type lamins.
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Blocking farnesylation of the ...... distribution of A-type lamins.
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Cecilia Ostlund
Gregg G Gundersen
Howard J Worman
Jason C Choi
Theresa C Swayne
Yuexia Wang
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P304
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10.4161/NUCL.21675
P577
2012-08-16T00:00:00Z