The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process.
about
Expression of Trypanosoma brucei gambiense Antigens in Leishmania tarentolae. Potential for Use in Rapid Serodiagnostic Tests (RDTs)The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.Direct analysis of mAb aggregates in mammalian cell culture supernatant.Functionalized micro-capillary film for the rapid at-line analysis of IgG aggregates in a cell culture bioreactor.Effect of bio-engineering on size, shape, composition and rigidity of bacterial microcompartments.IMAC capture of recombinant protein from unclarified mammalian cell feed streamsDifferential response in downstream processing of CHO cells grown under mild hypothermic conditions.Quantitative definition and monitoring of the host cell protein proteome using iTRAQ - a study of an industrial mAb producing CHO-S cell line.Influence of Escherichia coli chaperone DnaK on protein immunogenicity.Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives.An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants.A framework for the systematic design of fed-batch strategies in mammalian cell culture.Host cell protein dynamics in recombinant CHO cells: impacts from harvest to purification and beyond.Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry.Accounting for host cell protein behavior in anion-exchange chromatography.Development of adsorptive hybrid filters to enable two-step purification of biologics.Targeted purification development enabled by computational biophysical modeling.Development of robust antibody purification by optimizing protein-A chromatography in combination with precipitation methodologies.Clearance of the rodent retrovirus, XMuLV, by protein A chromatography.The effect of antiapoptosis genes on clarification performance.The challenges of product- and process-related impurities to an evolving biopharmaceutical industry.Two-Dimensional Gel Electrophoresis and 2D-DIGE.Host cell protein impurities in chromatographic polishing steps for monoclonal antibody purification.Development of advanced host cell protein enrichment and detection strategies to enable process relevant spike challenge studies.Trends in Upstream and Downstream Process Development for Antibody Manufacturing.Comparative Proteomic Analysis of Three Chinese Hamster Ovary (CHO) Host Cells.Characterization of Host Cell Proteins (HCPs) in CHO Cell Bioprocesses.A novel approach to characterize host cell proteins associated with therapeutic monoclonal antibodies.Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing.Recovery of Chinese hamster ovary host cell proteins for proteomic analysis.UV resonance Raman spectroscopy: a process analytical tool for host cell DNA and RNA dynamics in mammalian cell lines
P2860
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P2860
The dynamics of the CHO host cell protein profile during clarification and protein A capture in a platform antibody purification process.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
The dynamics of the CHO host c ...... antibody purification process.
@en
The dynamics of the CHO host c ...... antibody purification process.
@nl
type
label
The dynamics of the CHO host c ...... antibody purification process.
@en
The dynamics of the CHO host c ...... antibody purification process.
@nl
prefLabel
The dynamics of the CHO host c ...... antibody purification process.
@en
The dynamics of the CHO host c ...... antibody purification process.
@nl
P2093
P2860
P356
P1476
The dynamics of the CHO host c ...... antibody purification process.
@en
P2093
Andrew S Tait
C Mark Smales
Catherine E M Hogwood
Daniel G Bracewell
Nadejda Koloteva-Levine
P2860
P304
P356
10.1002/BIT.24607
P577
2012-08-06T00:00:00Z