Targeting isoprenoid biosynthesis for drug discovery: bench to bedside
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Staphylococcal response to oxidative stressExploring the role of receptor flexibility in structure-based drug discoveryAntibacterial drug leads targeting isoprenoid biosynthesisHIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid BiosynthesisDesign, Synthesis, Calorimetry, and Crystallographic Analysis of 2-Alkylaminoethyl-1,1-bisphosphonates as Inhibitors of Trypanosoma cruzi Farnesyl Diphosphate SynthaseSqualene synthase as a target for Chagas disease therapeuticsInsights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspHUtilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugsResistance-resistant antibioticsBioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infectionUse of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition.Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production.Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability.Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE InvestigationToxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to atorvastatinFarnesyl diphosphate synthase inhibitors with unique ligand-binding geometriesAdvanced paramagnetic resonance spectroscopies of iron-sulfur proteins: Electron nuclear double resonance (ENDOR) and electron spin echo envelope modulation (ESEEM)Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analoguesStructural characterization of substrate and inhibitor binding to farnesyl pyrophosphate synthase from Pseudomonas aeruginosa.Phenotypic Variation Is Almost Entirely Independent of the Host-Pathogen Relationship in Clinical Isolates of S. aureusAn antibiotic that inhibits a late step in wall teichoic acid biosynthesis induces the cell wall stress stimulon in Staphylococcus aureus.Broken-Symmetry DFT Computations for the Reaction Pathway of IspH, an Iron-Sulfur Enzyme in Pathogenic Bacteria2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthaseMechanistic studies of an IspH-catalyzed reaction: implications for substrate binding and protonation in the biosynthesis of isoprenoids.Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat HepatocytesFarnesyl diphosphate synthase inhibitors from in silico screening.Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni.Mechanistic aspects of carotenoid biosynthesis.Biochemistry of the non-mevalonate isoprenoid pathway.Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum.Neuroprotective Effects of Etidronate and 2,3,3-Trisphosphonate Against Glutamate-Induced Toxicity in PC12 Cells.Synergistic Activity between Statins and Bisphosphonates against Acute Experimental Toxoplasmosis.Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase.Structural and Chemical Biology of Terpenoid Cyclases.Nonselective mevalonate kinase inhibitor as a novel class of antibacterial agents.Novel single-nucleotide variations associated with vancomycin resistance in vancomycin-intermediate Staphylococcus aureus.Functional evidence for the critical amino-terminal conserved domain and key amino acids of Arabidopsis 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE.The stereochemical course and mechanism of the IspH reaction.
P2860
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P2860
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
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2010年學術文章
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2010年學術文章
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name
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside
@en
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
@nl
type
label
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside
@en
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
@nl
prefLabel
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside
@en
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside.
@nl
P2860
P356
P1476
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside
@en
P2093
Eric Oldfield
P2860
P304
P356
10.1021/AR100026V
P577
2010-09-01T00:00:00Z