A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states.
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Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to FunctionAMPK: An emerging target for modification of injury-induced pain plasticity.mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesiaTranslational control of nociception via 4E-binding protein 1Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulatorOpioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesiaAdenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain.Two complementary approaches for intracellular delivery of exogenous enzymes.Hyperbaric oxygen treatment attenuates neuropathic pain by elevating autophagy flux via inhibiting mTOR pathway.Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal hornIn vivo gene knockdown in rat dorsal root ganglia mediated by self-complementary adeno-associated virus serotype 5 following intrathecal delivery.Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis.mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.Mammalian target of rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in the rat.Evolution: the advantage of 'maladaptive' pain plasticity.Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice.Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesiamTOR kinase: a possible pharmacological target in the management of chronic pain.Gene expression profiling in pachyonychia congenita skinInvolvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain.Fragile X mental retardation protein (FMRP) and the spinal sensory system.Autophagy impairment in a mouse model of neuropathic painMechanisms and pharmacology of neuropathic pain in multiple sclerosis.Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain.Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats.Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain.Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia.Transient, activity dependent inhibition of transmitter release from low threshold afferents mediated by GABAA receptors in spinal cord lamina III/IV.Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in RatmTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injuryNeuropathic pain in animal models of nervous system autoimmune diseases.Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons.Peripheral administration of translation inhibitors reverses increased hyperalgesia in a model of chronic pain in the rat.Intact subepidermal nerve fibers mediate mechanical hypersensitivity via the activation of protein kinase C gamma in spared nerve injury.Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator.Blocking mammalian target of rapamycin alleviates bladder hyperactivity and pain in rats with cystitis.mTOR Inhibition: From Aging to Autism and Beyond.The mTOR signaling pathway regulates pain-related synaptic plasticity in rat entorhinal-hippocampal pathways.Blocking mammalian target of rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury.
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P2860
A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
A rapamycin-sensitive signalin ...... ion of persistent pain states.
@en
A rapamycin-sensitive signalin ...... ion of persistent pain states.
@nl
type
label
A rapamycin-sensitive signalin ...... ion of persistent pain states.
@en
A rapamycin-sensitive signalin ...... ion of persistent pain states.
@nl
prefLabel
A rapamycin-sensitive signalin ...... ion of persistent pain states.
@en
A rapamycin-sensitive signalin ...... ion of persistent pain states.
@nl
P2093
P2860
P50
P1476
A rapamycin-sensitive signalin ...... sion of persistent pain states
@en
P2093
J Lianne Leith
Keri K Tochiki
Sandrine M Géranton
Sarah A Stuart
Stephen P Hunt
P2860
P304
15017-15027
P356
10.1523/JNEUROSCI.3451-09.2009
P407
P577
2009-11-01T00:00:00Z