A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.
about
Targeting cellular metabolism to improve cancer therapeuticsTargeting Cancer Metabolism - Revisiting the Warburg EffectsNovel drugs that target the metabolic reprogramming in renal cell cancerMetabolomics in rheumatic diseases: desperately seeking biomarkersThe sweet trap in tumors: aerobic glycolysis and potential targets for therapyTargeting metabolism in breast cancer: How far we can go?Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor ProgressionThe Warburg effect and drug resistanceOvarian clear cell carcinoma meets metabolism; HNF-1β confers survival benefits through the Warburg effect and ROS reductionProgress toward overcoming hypoxia-induced resistance to solid tumor therapyNovel therapeutic targets of tumor metabolismCancer cell metabolism: implications for therapeutic targetsSLC transporters as therapeutic targets: emerging opportunitiesTargeting glycogen metabolism in bladder cancerROS homeostasis and metabolism: a critical liaison for cancer therapyAdipose tissue dysfunction and its effects on tumor metabolismMolecular Connections between Cancer Cell Metabolism and the Tumor MicroenvironmentWZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site.Co-expression of CD147 and GLUT-1 indicates radiation resistance and poor prognosis in cervical squamous cell carcinoma.Current views on cell metabolism in SDHx-related pheochromocytoma and paragangliomaTargeting MYC Dependence by Metabolic Inhibitors in CancerConstituents of an extract of Cryptocarya rubra housed in a repository with cytotoxic and glucose transport inhibitory effectsThe distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition.In vivo evaluation of the effects of simultaneous inhibition of GLUT-1 and HIF-1α by antisense oligodeoxynucleotides on the radiosensitivity of laryngeal carcinoma using micro 18F-FDG PET/CTStroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitorsReprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro studyTumor bioenergetics: an emerging avenue for cancer metabolism targeted therapyMechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.TP53 mutation hits energy metabolism and increases glycolysis in breast cancer.The Warburg effect: evolving interpretations of an established conceptTargeting the facilitative glucose transporter GLUT1 inhibits the self-renewal and tumor-initiating capacity of cancer stem cells.Metabolic signature identifies novel targets for drug resistance in multiple myeloma.Molecular Pathways: Targeting Cellular Energy Metabolism in Cancer via Inhibition of SLC2A1 and LDHAFasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual ScreeningIdentification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876.A Novel Fluorescence Resonance Energy Transfer-Based Screen in High-Throughput Format To Identify Inhibitors of Malarial and Human Glucose TransportersCardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models
P2860
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P2860
A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
A small-molecule inhibitor of ...... l growth in vitro and in vivo.
@en
A small-molecule inhibitor of ...... l growth in vitro and in vivo.
@nl
type
label
A small-molecule inhibitor of ...... l growth in vitro and in vivo.
@en
A small-molecule inhibitor of ...... l growth in vitro and in vivo.
@nl
prefLabel
A small-molecule inhibitor of ...... l growth in vitro and in vivo.
@en
A small-molecule inhibitor of ...... l growth in vitro and in vivo.
@nl
P2093
P1476
A small-molecule inhibitor of ...... ll growth in vitro and in vivo
@en
P2093
Huzoor Akbar
Jennifer Hines
Lingying Tong
Robert Colvin
Shiyong Wu
Xiaozhuo Chen
Yanrong Qian
Yanyan Cao
P304
P356
10.1158/1535-7163.MCT-12-0131
P577
2012-06-11T00:00:00Z