about
A gene network regulating lysosomal biogenesis and functionA block of autophagy in lysosomal storage disordersTrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migrationMechanism of TrkB-mediated hippocampal long-term potentiationA lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEBA reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional dataThe phytoestrogen genistein modulates lysosomal metabolism and transcription factor EB (TFEB) activationLysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders.Signals from the lysosome: a control centre for cellular clearance and energy metabolism.Transcriptional activation of lysosomal exocytosis promotes cellular clearance.SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRLTFEB-mediated increase in peripheral lysosomes regulates store-operated calcium entryLysosomal calcium regulates autophagy.High-content drug screening for rare diseases.Methods to Monitor and Manipulate TFEB Activity During Autophagy.Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells.Brain Disorders Due to Lysosomal Dysfunction.TRPML1: The Ca((2+))retaker of the lysosome.Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition.FGF signalling regulates bone growth through autophagy.Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E x cyclin-dependent kinase 2 complexes.The MDM2 oncoprotein promotes apoptosis in p53-deficient human medullary thyroid carcinoma cells.Introduction of p53 induces cell-cycle arrest in p53-deficient human medullary-thyroid-carcinoma cells.A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies.RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity.Somatostatin is expressed in FRTL-5 thyroid cells and prevents thyrotropin-mediated down-regulation of the cyclin-dependent kinase inhibitor p27kip1.TFEB and the CLEAR networkCystic fibrosis: A disorder with defective autophagymTOR-dependent phosphorylation controls TFEB nuclear exportGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)The activity of Sac1 across ER-TGN contact sites requires the four-phosphate-adaptor-protein-1TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathwayTFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response
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Q24339409-7B7E40CF-B0E9-41A5-B828-4A46473D9247Q28252016-8424939C-593F-4F59-B3A5-A9E65F7083B5Q28589456-138D225F-BEB4-4D3B-BF02-C3A18C7D7EDBQ28592383-0840FB6E-314F-4A14-A6F8-B4DE2F1D6D13Q30508509-AE95FD75-4BB5-4286-84BE-7283363E3DA9Q30991256-75A113A4-1E93-4DCD-9567-06118D307F99Q33761283-466F3632-5585-4662-8C4E-73FDE66C39D5Q34140173-BB048054-BE4F-479C-8089-2671273F776AQ34340780-1194F888-80DA-40B9-841A-C28D8C812DD4Q35214694-6A1C527B-CBB7-4EB2-8EE6-47B5DF014CDCQ36240441-70745933-73DD-4804-91E6-48AAB8AD7A70Q36709792-4A730228-D0B0-4411-922F-CE397BB72F73Q37292836-18C4B84F-F545-4672-B1FC-F2051E41777AQ37584458-81F1B16E-EAAE-4876-9F01-C1E867869167Q38497949-F5F06BCC-1D6E-43B9-8E33-1AB4A4F83F4CQ38673430-98CA5833-82B1-4D6E-B96B-68F0C94D15AFQ38753315-1B18C47A-A2F8-45B7-A889-C54FB275C210Q38784895-DF7231E1-6E69-4364-8EA6-84A2DB57B702Q38811324-109C4538-210C-44F5-B8F8-67E3D3C7E9E8Q39423857-8384DF53-D619-4BCD-8EF8-3E79D1B2DA99Q39667316-77B44137-F065-4B0C-A1C6-FD3B450F0464Q40288311-5A6593EA-918A-46B5-A998-D35B7F177613Q40880066-392A433B-154A-45BA-BAD9-DED97002B1B3Q40909517-C160C6CA-BFF9-4379-9423-D4EF365B7E80Q41080587-ADC70233-DDA5-411A-A800-06812523AA5BQ42390437-72FC1246-4BA2-4C85-8714-1003B1057887Q42487275-246AA95B-17A5-44B7-B11C-D41C2BA50DAFQ53393296-493C170B-4849-4B3D-AB12-CBDB750B9FAFQ53427367-96B87578-3135-4B34-B52D-6609FEAFCEBDQ57663463-93562322-1011-48DF-BBFD-3BDAEF961D00Q57663495-3C43CD16-103C-4564-86ED-C6379890D097Q58770831-B8C3A34C-CA0E-4741-A2C2-C487A5C1873AQ87139132-3BCC3789-4028-4561-A8CF-1E315FB02057Q91117017-811DC447-7862-4139-AE45-140F308E4AC8Q91854257-4D51BDC1-B920-464D-ADE6-C55C7DA8D60EQ94593181-74A86B8C-BF2B-43CA-BB50-BA104D717E37
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description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Diego Luis Medina
@ast
Diego Luis Medina
@en
Diego Luis Medina
@es
Diego Luis Medina
@nl
Diego Luis Medina
@sl
type
label
Diego Luis Medina
@ast
Diego Luis Medina
@en
Diego Luis Medina
@es
Diego Luis Medina
@nl
Diego Luis Medina
@sl
altLabel
Medina DL
@en
prefLabel
Diego Luis Medina
@ast
Diego Luis Medina
@en
Diego Luis Medina
@es
Diego Luis Medina
@nl
Diego Luis Medina
@sl
P106
P1153
7102063349
P21
P2798
P31
P4012
P496
0000-0002-7347-2645