Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
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Nuclear receptors and AMPK: can exercise mimetics cure diabetes?Fibroblast Growth Factor Signaling in Metabolic RegulationInventing new medicines: The FGF21 storyStressed Liver and Muscle Call on Adipocytes with FGF21FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic DiseasesInhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon ReceptorFibroblast Growth Factor 21 Analogs for Treating Metabolic Disorders.Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizerMetabolic role of fibroblast growth factor 21 in liver, adipose and nervous system tissues.FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissuePotent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO miceFGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss.The Fibroblast Growth Factor signaling pathwayMonoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.Antibody-mediated activation of FGFR1 induces FGF23 production and hypophosphatemia.FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation.Receptor antibodies as novel therapeutics for diabetes.Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex.βKlotho is required for fibroblast growth factor 21 effects on growth and metabolismIL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db MiceObesity surgery: happy with less or eternally hungry?Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification.The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.MicroRNA-34a and Impaired FGF19/21 Signaling in ObesityFGF21 mimetic shows therapeutic promise.FGF19 action in the brain induces insulin-independent glucose loweringMetabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A (1)H NMR-based metabolomics investigation.Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humans.Tanycytes As Regulators of Seasonal Cycles in Neuroendocrine Function.Nuclear receptors and metabolism: from feast to famine.Cooperation between brain and islet in glucose homeostasis and diabetes.An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities.Dual actions of fibroblast growth factor 19 on lipid metabolism.Effect of mitochondrial stress on systemic metabolism.FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus.
P2860
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P2860
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Amelioration of type 2 diabete ...... last growth factor receptor 1.
@en
Amelioration of type 2 diabete ...... last growth factor receptor 1.
@nl
type
label
Amelioration of type 2 diabete ...... last growth factor receptor 1.
@en
Amelioration of type 2 diabete ...... last growth factor receptor 1.
@nl
prefLabel
Amelioration of type 2 diabete ...... last growth factor receptor 1.
@en
Amelioration of type 2 diabete ...... last growth factor receptor 1.
@nl
P2093
P2860
P1476
Amelioration of type 2 diabete ...... last growth factor receptor 1.
@en
P2093
Ai-Luen Wu
Andrew S Peterson
Daniel Yansura
David West
Elizabeth Luis
Ellen Filvaroff
Ganesh Kolumam
Hok Seon Kim
P2860
P304
P356
10.1126/SCITRANSLMED.3002669
P407
P577
2011-12-01T00:00:00Z