Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.
about
Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors.The role of histone ubiquitination during spermatogenesis.Metabolic Effects of Known and Novel HDAC and SIRT Inhibitors in Glioblastomas Independently or Combined with TemozolomideQuantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.Miniature short hairpin RNA screens to characterize antiproliferative drugsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligaseDNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death.USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammationStress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2.Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro.Histone deacetylase inhibitors and cell death.Honokiol induces cell cycle arrest and apoptosis via inhibiting class I histone deacetylases in acute myeloid leukemia.Susceptibility of hepatoma-derived cells to histone deacetylase inhibitors is associated with ID2 expression.Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress.Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.Return to quiescence of mouse neural stem cells by degradation of a proactivation protein.Inhibitors of histone deacetylases enhance neurotoxicity of DNA damagec-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner.Ubiquitination by HUWE1 in tumorigenesis and beyondUbiquitin Regulation: The Histone Modifying Enzyme's StoryTricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth
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Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.
description
2011 nî lūn-bûn
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2011年の論文
@ja
2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
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2011年學術文章
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2011年學術文章
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name
Mule determines the apoptotic ...... tion and destruction of HDAC2.
@en
Mule determines the apoptotic ...... tion and destruction of HDAC2.
@nl
type
label
Mule determines the apoptotic ...... tion and destruction of HDAC2.
@en
Mule determines the apoptotic ...... tion and destruction of HDAC2.
@nl
prefLabel
Mule determines the apoptotic ...... tion and destruction of HDAC2.
@en
Mule determines the apoptotic ...... tion and destruction of HDAC2.
@nl
P2093
P2860
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P1476
Mule determines the apoptotic ...... tion and destruction of HDAC2.
@en
P2093
P2860
P304
P356
10.1101/GAD.170605.111
P577
2011-10-20T00:00:00Z