Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.
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The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complexDAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosisFBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascadeIncreased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinaseOverexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/AktReduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetesDynamic modules and heterogeneity of function: a lesson from tyrosine kinase receptors in endothelial cellsExpression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patientsPositive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signalingDirect positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.TOR signaling.Hemorrhage and subsequent allogenic red blood cell transfusion are associated with characteristic monocyte messenger RNA expression patterns in patients after multiple injury-a genome wide viewPhosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85alphaNonprofessional phagocytosis can facilitate herpesvirus entry into ocular cells.Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.New responsibilities for the PI3K regulatory subunit p85 alpha.p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.Direct association of heat shock protein 20 (HSPB6) with phosphoinositide 3-kinase (PI3K) in human hepatocellular carcinoma: regulation of the PI3K activity.Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin populationSpecific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alphaClass IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.Therapeutic potential of target of rapamycin inhibitors.p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity.Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartumAcute effects of different diet compositions on skeletal muscle insulin signalling in obese individuals during caloric restriction.PI3-kinase mutation linked to insulin and growth factor resistance in vivoLow conservation and species-specific evolution of alternative splicing in humans and mice: comparative genomics analysis using well-annotated full-length cDNAs.SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling.Adipose tissue insulin sensitivity and macrophage recruitment: Does PI3K pick the pathway?Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression.Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats.Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism: a double blind, randomized, controlled cross-over study.Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding.High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical TrialInsulin signaling meets mitochondria in metabolism.Therapeutic targeting of EGFR-activated metabolic pathways in glioblastoma.
P2860
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P2860
Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit.
description
2000 nî lūn-bûn
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2000年の論文
@ja
2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
@zh-my
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2000年學術文章
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name
Positive and negative regulati ...... e p85alpha regulatory subunit.
@en
Positive and negative regulati ...... e p85alpha regulatory subunit.
@nl
type
label
Positive and negative regulati ...... e p85alpha regulatory subunit.
@en
Positive and negative regulati ...... e p85alpha regulatory subunit.
@nl
prefLabel
Positive and negative regulati ...... e p85alpha regulatory subunit.
@en
Positive and negative regulati ...... e p85alpha regulatory subunit.
@nl
P2093
P2860
P1476
Positive and negative regulati ...... e p85alpha regulatory subunit.
@en
P2093
F Mauvais-Jarvis
P Algenstaedt
P2860
P304
P356
10.1128/MCB.20.21.8035-8046.2000
P407
P577
2000-11-01T00:00:00Z