Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivity.
about
Targeting DNA With Fingers and TALENsZinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleasesTAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domainDe novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaksZinc-finger nuclease-induced gene repair with oligodeoxynucleotides: wanted and unwanted target locus modificationsZinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cellsMaking designer mutants in model organismsRevealing off-target cleavage specificities of zinc-finger nucleases by in vitro selectionDirected evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleasesEnhancing zinc-finger-nuclease activity with improved obligate heterodimeric architecturesTargeted mutagenesis of duplicated genes in soybean with zinc-finger nucleasesGenome Engineering With Zinc-Finger NucleasesOligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arraysTALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicityZFN-site searches genomes for zinc finger nuclease target sites and off-target sites.Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs.ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool.Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases.A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.Controlling gene networks and cell fate with precision-targeted DNA-binding proteins and small-molecule-based genome readers.Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion.Highly active zinc-finger nucleases by extended modular assemblyGlobal analysis of Drosophila Cys₂-His₂ zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants.The generation of zinc finger proteins by modular assembly.A novel genetic system based on zinc finger nucleases for the identification of interactions between proteins in vivo.Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases.Zinc-finger nucleases for somatic gene therapy: the next frontier.Targeted germ line disruptions reveal general and species-specific roles for paralog group 1 hox genes in zebrafishRescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineeringA large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly.Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification.Zinc Finger Nucleases: Tailor-made for Gene TherapyAn update on targeted gene repair in mammalian cells: methods and mechanismsTowards artificial metallonucleases for gene therapy: recent advances and new perspectives.Molecular scissors for in situ cellular repair.Targeted gene therapies: tools, applications, optimizationNew developments in the use of gene therapy to treat Duchenne muscular dystrophy.Precision genome editing: a small revolution for glycobiology.
P2860
Q24599859-DA3283BE-C4F0-466E-A582-E15DB45C1280Q24603161-BD50260D-DC0A-4D6B-8F54-D246B28FC85CQ24603277-5143AB58-E37E-424B-A7EF-C3C7452E6C56Q24624851-2D1C778B-11EB-4585-8915-FA2AA81DF076Q24630071-378B9B52-5676-439D-BB98-15114DDAF51CQ24658337-00C9ABC3-3DD2-4C3C-BDB7-11A41D19D93AQ27010108-6CD91F17-3EA1-4F60-AABA-F26306CFCB6AQ28245039-C4189E5F-76F9-4673-AA40-2D63C0B5D8EAQ28281488-F69232F7-6AA6-4BB7-85BF-427752769265Q28299915-8FA7D086-5817-4E35-B1EA-934D2F9B1307Q28308217-904C4C3F-980A-49CD-9855-BFDC514C8DBFQ29301748-EA4BF8A2-C827-4D32-BF77-D789DEB4F13BQ33508083-7A728BFF-B263-49AB-87A9-3286586A9670Q33698693-1C464561-D418-4EA8-BF8F-C9EF9F540EA0Q33899058-96B79EA2-A0CC-4E4D-A207-42347FEA84BFQ33931634-18A893B1-D4F9-4046-9A2A-2F7ABDFFF16AQ33957629-B4B8B8A5-D493-4BEC-B8BA-65F1219DFFB7Q34110518-323FF7E3-82BA-4992-8E0A-F102ACD8EE81Q34205743-B398E88B-640E-4E9A-BEB5-6BD4EBDE86DBQ34381076-821FFAFD-160D-4E23-9A2E-4E022C149C3AQ34401485-5E6AE4B3-9C8E-4C7F-AB75-1EA9D48A9508Q34504179-E88AFFE3-A333-4E81-A774-50143DD6E332Q34614125-A0A4B31C-FA04-4E8F-9F3A-33AFB437C3BBQ35069388-84DD354A-1144-4156-99EA-B3DA6426B919Q35083171-36B41F7F-9513-48F6-B35C-3308CDD01C7DQ35153108-3DB97C5A-4B39-48FC-B29A-3C5B5AF84426Q35174917-4E957143-7EF9-441E-A046-D41A6D429085Q35182464-0BE58D77-BCAC-4784-9784-242CF77F6C70Q35637089-4BE82032-7EAD-4E96-9F07-091A5F11FCDFQ35823895-46DE2D40-2305-40D2-B72C-87B0ECF16EA5Q36491274-E74C1EC1-57E5-4ED7-8A9E-FE709435323CQ36619882-C88F713A-8D81-477D-9395-32D49FEDE8F1Q36832219-68250921-6168-444D-9D77-8649221B9042Q37241457-C465E3EA-84F0-46E1-A2EA-54C06C96132BQ37834094-3117738A-3EEA-4E60-9508-F6E09395544AQ37948867-C24DEC68-6810-4423-8726-899EC1586796Q37979243-56F2AF56-A018-4904-B481-4F087BC243B3Q38005211-55661925-E377-416E-8D54-0CEA13EFECFAQ38168863-7DF3BC05-9B59-4357-AA8A-6C08A2FEAC15Q38214809-D95BEFD4-F9CE-4C90-90B8-260898C40A78
P2860
Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivity.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Expanding or restricting the t ...... nt of target site selectivity.
@en
Expanding or restricting the t ...... nt of target site selectivity.
@nl
type
label
Expanding or restricting the t ...... nt of target site selectivity.
@en
Expanding or restricting the t ...... nt of target site selectivity.
@nl
prefLabel
Expanding or restricting the t ...... nt of target site selectivity.
@en
Expanding or restricting the t ...... nt of target site selectivity.
@nl
P2860
P356
P1433
P1476
Expanding or restricting the t ...... nt of target site selectivity.
@en
P2093
Eva-Maria Händel
Stephen Alwin
P2860
P304
P356
10.1038/MT.2008.233
P577
2008-11-11T00:00:00Z