Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity. - Wikidata - wikimedia - TriplyDB

Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

http://www.wikidata.org/entity/Q39507945

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Glial-derived neurotrophic factor gene transfer for Parkinson's disease: anterograde distribution of AAV2 vectors in the primate brain GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects.Transduction of brain dopamine neurons by adenoviral vectors is modulated by CAR expression: rationale for tropism modified vectors in PD gene therapy Glial cell line-derived neurotrophic factor gene therapy ameliorates chronic hyperprolactinemia in senile rats.Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.Guided delivery of adeno-associated viral vectors into the primate brain Widespread cortical expression of MANF by AAV serotype 7: localization and protection against ischemic brain injury.InsR/FoxO1 signaling curtails hypothalamic POMC neuron number.Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake Functional neuroprotection and efficient regulation of GDNF using destabilizing domains in a rodent model of Parkinson's disease.Weight changes in subthalamic nucleus vs globus pallidus internus deep brain stimulation: results from the COMPARE Parkinson disease deep brain stimulation cohort.A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model.MAP kinases couple hindbrain-derived catecholamine signals to hypothalamic adrenocortical control mechanisms during glycemia-related challenges.CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease.Efficient Expression of Igf-1 from Lentiviral Vectors Protects In Vitro but Does Not Mediate Behavioral Recovery of a Parkinsonian Lesion in Rats.Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes.A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses.Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients.Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity.Glial Cell Line-Derived Neurotrophic Factor Gene Delivery in Parkinson's Disease: A Delicate Balance between Neuroprotection, Trophic Effects, and Unwanted Compensatory Mechanisms.Gene therapy for Parkinson's disease: where are we now and where are we going?AAV2-neurturin (CERE-120) for Parkinson's disease.A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting.Gene therapy for Parkinson's disease: state-of-the-art treatments for neurodegenerative disease.Identifying links in the chain: the dynamic coupling of catecholamines, peptide synthesis, and peptide release in hypothalamic neuroendocrine neurons.Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications Viral vector delivery of neurotrophic factors for Parkinson's disease therapy.Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model.Tet-On Systems For Doxycycline-inducible Gene Expression.Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector.Anterograde axonal transport of AAV2-GDNF in rat basal ganglia Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain.Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial.The role of parkin in the differential susceptibility of tuberoinfundibular and nigrostriatal dopamine neurons to acute toxicant exposure.

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P2860

Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.

http://www.wikidata.org/entity/Q39507945

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2009年論文

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2009年论文

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2009年论文

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2009年论文

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name

Nigrostriatal rAAV-mediated GD ...... model of age-related obesity.

@en

Nigrostriatal rAAV-mediated GD ...... model of age-related obesity.

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type

label

Nigrostriatal rAAV-mediated GD ...... model of age-related obesity.

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Nigrostriatal rAAV-mediated GD ...... model of age-related obesity.

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prefLabel

Nigrostriatal rAAV-mediated GD ...... model of age-related obesity.

@en

Nigrostriatal rAAV-mediated GD ...... model of age-related obesity.

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Molecular Therapy

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Nigrostriatal rAAV-mediated GD ...... t model of age-related obesity

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Aaron C Rising

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Christopher S Broxson

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Fredric P Manfredsson

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Kevin D Foust

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Layla F Sullivan

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Nicholas Muzyczka

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Nihal Tumer

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Oleg S Gorbatyuk

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Philip J Scarpace

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Ronald J Mandel

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P2860

GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse

Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons

GDNF family receptor complexes are emerging drug targets

Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice

Central nervous system control of food intake and body weight

Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer.

Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins.

Characterization of a multicomponent receptor for GDNF.

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