Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination.
about
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3betaFBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activityA comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome systemTyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulationMDM2-HDAC1-mediated deacetylation of p53 is required for its degradationTranscriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexesZBP-89 promotes growth arrest through stabilization of p53Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteinsUbiquitylation of an ERAD substrate occurs on multiple types of amino acidsp53 Acetylation: Regulation and ConsequencesMDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylationIdentification of the preferential ubiquitination site and ubiquitin-dependent degradation signal of Rpn4The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitinationReconstitution of Mdm2-dependent post-translational modifications of p53 in yeast.C-terminal ubiquitination of p53 contributes to nuclear exportFunctional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity.p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels.MDM2 mediates ubiquitination and degradation of activating transcription factor 3ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter.HCMV IE2-mediated inhibition of HAT activity downregulates p53 function.The evolution of diverse biological responses to DNA damage: insights from yeast and p53.A protein turnover signaling motif controls the stimulus-sensitivity of stress response pathwaysSubunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activityThe tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.Proteomic analysis reveals differentially regulated protein acetylation in human amyotrophic lateral sclerosis spinal cord.Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damageRegulation of p53 responses by post-translational modifications.The complex interactions of p53 with target DNA: we learn as we go.MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.Getting into position: the catalytic mechanisms of protein ubiquitylation.Post-translational modification of p53 in tumorigenesis.A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells.Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication.Mouse bites dogma: how mouse models are changing our views of how P53 is regulated in vivo.Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo.Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity.Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis.PDL1 Regulation by p53 via miR-34The MDM2-p53 pathway revisited
P2860
Q24306430-BA021CB6-038C-443F-B9D6-D260593193A1Q24314409-0535228F-E481-413B-A14E-7875F29BE898Q24336529-0D2C4E8E-6525-41F3-A48A-DE9084983208Q24534983-C4400CB1-3AD1-4519-871A-02876A611A67Q24537700-1369A4D0-6F13-4FE8-BCB3-197E50529FACQ24537716-DD05465E-7079-47A4-815D-7E2C26E66893Q24550923-69A4428C-2CBE-4462-AE30-7D935B8AB19AQ24677861-5EE32ED9-6831-45C1-A58A-0BA2BCCAC090Q26781978-63187D84-FFA1-413E-9A03-D254C4A25B9AQ28085076-A09981E1-E14A-40D5-ABEE-6BA6058A6BAEQ28204918-97F4FABF-E7F5-4C37-B6C3-1F269EA4F0E8Q28298559-FFAD6C7E-0B57-4F78-B241-B5FA3D50E411Q28743328-91AA4C90-83BA-4C52-A233-6CB2C643B135Q33317275-18F573B4-C819-42C5-A86D-08E1CE199272Q33551236-7C1C8055-C8D2-4C4B-9BE0-E31C5CCAA94FQ33863075-46B7E280-2947-4E73-B26B-B9FB61645FAFQ33905382-94202810-4B3C-4762-B9EA-DF54EFDBDF24Q34094359-E55FB5BA-0723-4667-836D-8AEC830F54B5Q34109489-00C47EEB-23ED-4CB9-A957-4575B354F854Q34348863-7365D282-E982-4A38-82C5-CD3BB98454B1Q34487385-71AE7BCD-B9DA-45DC-BC9C-136375B1C985Q34611097-29529B66-4CBF-4896-AE24-94B0B3618C3BQ34627210-61B70B1C-5B2F-444D-8E02-C00842CDDC89Q34800116-D8AD6373-1408-41A4-82AD-EACF3EA6B1E6Q34888585-BB15DDC3-86B7-460D-93F9-FFA6FE123C65Q35061120-DDB566CB-1F84-40CD-AA5A-4E4AE6772B41Q35071254-EAD3A27A-6527-4657-A18B-C27856F4D8C4Q35116637-D6EBBCF1-34FA-4048-B4E2-E1F27C2859E7Q35191541-EF9D5B34-79C0-43BD-BF75-70C98107DB78Q35196526-7C312CE1-7A3B-4C26-BF0C-D9DB4AEC5FDDQ35681247-DDC124D9-E279-4BC1-BE29-29FE0547EAEFQ35930703-BFE910B0-3F4D-4950-B4A9-27916EC019B8Q36114705-63D4C753-5300-4AFB-A38E-9E4BAF7EAFF8Q36216436-E6EDEB4D-CD58-4A84-B767-B1AB3412C90AQ36436702-A4B79AC4-E0B1-47CB-8B34-E93E166FEC67Q36601373-5BA1BDDE-275C-4D5D-B87B-1EF71994F1D5Q36732343-2668F24C-9C69-486C-A9AD-407D28DACAC5Q36849135-BF141C5F-82E6-48ED-98E0-BFC1ADF1A424Q36887608-8096B6A9-DF3C-42AB-BDD7-F82B2614223AQ37039474-D144DCF0-1D97-4211-AB11-00490519FE16
P2860
Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Multiple lysine mutations in t ...... egradation and ubiquitination.
@en
Multiple lysine mutations in t ...... egradation and ubiquitination.
@nl
type
label
Multiple lysine mutations in t ...... egradation and ubiquitination.
@en
Multiple lysine mutations in t ...... egradation and ubiquitination.
@nl
prefLabel
Multiple lysine mutations in t ...... egradation and ubiquitination.
@en
Multiple lysine mutations in t ...... egradation and ubiquitination.
@nl
P2093
P2860
P1476
Multiple lysine mutations in t ...... egradation and ubiquitination.
@en
P2093
S Nakamura
T Mukhopadhyay
P2860
P304
P356
10.1128/MCB.20.24.9391-9398.2000
P407
P577
2000-12-01T00:00:00Z