Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity.
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Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradationEffects of MdmX on Mdm2-mediated downregulation of pRBPhosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 bindingMDMX regulation of p53 response to ribosomal stressThe PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cellsMdmX is a substrate for the deubiquitinating enzyme USP2aDNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma developmentRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1Small molecule compounds targeting the p53 pathway: are we finally making progress?Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in transActivation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerizationThe Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic TargetRegulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damageG1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target PtprvMDM2 and MDMX: Alone and together in regulation of p53Noncanonical microRNAs and endogenous siRNAs in normal and psoriatic human skinDiscovery and preclinical validation of salivary transcriptomic and proteomic biomarkers for the non-invasive detection of breast cancerp53 ubiquitination: Mdm2 and beyondMisfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.MDM4 (MDMX) and its Transcript Variants.Mutation analysis of the MDM4 gene in German breast cancer patientsIdentification and characterization of the first small molecule inhibitor of MDMXDifferences in the transactivation domains of p53 family members: a computational study.High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia.Methylation profile of TP53 regulatory pathway and mtDNA alterations in breast cancer patients lacking TP53 mutations.Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.The regulation of the p53-mediated stress response by MDM2 and MDM4.Tumorigenesis promotes Mdm4-S overexpression.The role of MDM2 and MDM4 in breast cancer development and prevention.Beta-peptides with improved affinity for hDM2 and hDMX.HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4MDM2, MDMX and p53 in oncogenesis and cancer therapyValidation of MdmX as a therapeutic target for reactivating p53 in tumorsP53 mdm2 inhibitors.MicroRNA-34a modulates MDM4 expression via a target site in the open reading frameA fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53.p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors.
P2860
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P2860
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Amplification of Mdmx (or Mdm4 ...... p53 tumor suppressor activity.
@ast
Amplification of Mdmx (or Mdm4 ...... p53 tumor suppressor activity.
@en
type
label
Amplification of Mdmx (or Mdm4 ...... p53 tumor suppressor activity.
@ast
Amplification of Mdmx (or Mdm4 ...... p53 tumor suppressor activity.
@en
prefLabel
Amplification of Mdmx (or Mdm4 ...... p53 tumor suppressor activity.
@ast
Amplification of Mdmx (or Mdm4 ...... p53 tumor suppressor activity.
@en
P2093
P2860
P50
P1476
Amplification of Mdmx (or Mdm4 ...... p53 tumor suppressor activity.
@en
P2093
Aart G Jochemsen
Alberto Gobbi
Domenico Migliorini
Erik Meulmeester
Maria Capra
Pier Giuseppe Pelicci
Ruth Frenk
P2860
P304
P356
10.1128/MCB.24.13.5835-5843.2004
P407
P50
P577
2004-07-01T00:00:00Z