Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation.
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Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblastsVisualization of biochemical networks in living cellsDysregulated TCL1 promotes multiple classes of mature B cell lymphoma.The COOH-terminal domain of wild-type Cot regulates its stability and kinase specific activityEnhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.Phase II study of everolimus with biomarker exploration in patients with advanced gastric cancer refractory to chemotherapy including fluoropyrimidine and platinumRegulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation siteGlucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1Hierarchical phosphorylation of the translation inhibitor 4E-BP1A role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscleTuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independentDomain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinaseThe rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.TOR signaling.Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylationInsulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner.An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice.Cellular function of p70S6K: a role in regulating cell motility.4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle.Electromechanical modulation of catabolic and anabolic pathways in chronically inactive, but neurally intact, muscles.Lipid signaling in T-cell development and functionAkt/protein kinase B promotes organ growth in transgenic mice.mTOR signaling for biological control and cancer.Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.Transgenic analysis of thymocyte signal transduction.A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster.The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression.Rett syndrome: genes, synapses, circuits, and therapeuticsFunctional and therapeutic significance of Akt deregulation in malignant melanoma.Time-varying causal inference from phosphoproteomic measurements in macrophage cellsThe conserved phosphoinositide 3-kinase pathway determines heart size in mice.Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosisAlteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin.Phosphoinositide 3-kinase signaling in the vertebrate retina.
P2860
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P2860
Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Protein kinase B localization ...... ing protein 1 phosphorylation.
@en
Protein kinase B localization ...... ing protein 1 phosphorylation.
@nl
type
label
Protein kinase B localization ...... ing protein 1 phosphorylation.
@en
Protein kinase B localization ...... ing protein 1 phosphorylation.
@nl
prefLabel
Protein kinase B localization ...... ing protein 1 phosphorylation.
@en
Protein kinase B localization ...... ing protein 1 phosphorylation.
@nl
P2093
P2860
P356
P1476
Protein kinase B localization ...... ing protein 1 phosphorylation.
@en
P2093
B A Hemmings
B M Burgering
M Andjelkovic
P2860
P304
P356
10.1128/MCB.19.6.4525
P407
P577
1999-06-01T00:00:00Z