The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.

The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.

Item
http://www.wikidata.org/entity/Q39578758
A sensitive liquid chromatography-mass spectrometry bioanalytical assay for a novel anticancer candidate--ZMC1.Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1.Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes.Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelatorsThe anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).Iron Chelators and Exogenic Photosensitizers. Synergy through Oxidative Stress Gene Expression.The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism.
P2860

The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.

Item
http://www.wikidata.org/entity/Q39578758
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The potent and novel thiosemic ...... nucleotide reductase activity.
@en
The potent and novel thiosemic ...... nucleotide reductase activity.
@nl
type
label
The potent and novel thiosemic ...... nucleotide reductase activity.
@en
The potent and novel thiosemic ...... nucleotide reductase activity.
@nl
prefLabel
The potent and novel thiosemic ...... nucleotide reductase activity.
@en
The potent and novel thiosemic ...... nucleotide reductase activity.
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
The potent and novel thiosemic ...... onucleotide reductase activity
@en
P2093
P304
P31
P356
P433
P478
P50
P577
P5875
P698