The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).
about
The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targetsTargeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genesIron and cancer: more ore to be mined.N-myc downstream-regulated gene 1 inhibits the proliferation and invasion of hepatocellular carcinoma cells via the regulation of integrin β3The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.N-myc downstream regulated 1 (NDRG1) is regulated by eukaryotic initiation factor 3a (eIF3a) during cellular stress caused by iron depletion.The expression and localization of N-myc downstream-regulated gene 1 in human trophoblasts.Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathwaysThe proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1.Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells.NDRG1 attenuates epithelial-mesenchymal transition of nasopharyngeal cancer cells via blocking Smad2 signaling.Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasisN-myc downstream regulated gene 1 (NDRG1) promotes metastasis of human scirrhous gastric cancer cells through epithelial mesenchymal transition.Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression.Deep-proteome mapping of WM-266-4 human metastatic melanoma cells: From oncogenic addiction to druggable targetsTargeting cancer by binding iron: Dissecting cellular signaling pathwaysThe Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling PathwaysThe metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44.Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types.Dp44mT targets the AKT, TGF-β and ERK pathways via the metastasis suppressor NDRG1 in normal prostate epithelial cells and prostate cancer cells.Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter.Valproic acid inhibits the invasion of PC3 prostate cancer cells by upregulating the metastasis suppressor protein NDRG1.Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.AKAP-9 promotes colorectal cancer development by regulating Cdc42 interacting protein 4.Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling.Proteolytic cleavage and truncation of NDRG1 in human prostate cancer cells, but not normal prostate epithelial cells.The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer.MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activationN-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cellsNDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway.The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms.N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)The iron chelator Dp44mT suppresses osteosarcoma's proliferation, invasion and migration: in vitro and in vivoNDRG1 deficiency attenuates fetal growth and the intrauterine response to hypoxic injury.The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.Iron chelation in the treatment of cancer: a new role for deferasirox?The role of NDRG1 in the pathology and potential treatment of human cancers.NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis.
P2860
Q26782593-FFFCFA06-1063-40A4-8E19-3372A6E45C5CQ27853201-FD55B699-2CE7-4BA4-B124-356F15A00BF8Q33677592-2D006DAE-854C-4870-AB97-B2F52856A89AQ33685302-30044807-1898-41E8-9CD2-C31068A58AD4Q34580395-ED050F50-B5C2-43F1-BF22-CB571B52646EQ34600331-107B0D5D-F38F-4A8B-A4FC-15C89114B0F4Q34997521-1BECA357-510B-4D99-B0B3-B2BCCD5020CEQ35351758-182EF87E-D5DD-4461-B7BC-A4A7C00D798FQ35628577-377DCF3C-F331-4238-A1EC-1E2C598BD424Q35832242-4B9E26D1-39DD-491F-B811-4B39398D7B9CQ35833012-D7F4B417-462C-48F1-8CC8-CEA73E41E0ABQ36032766-FD6EC905-42BA-4644-9D1C-4C602AE20D2DQ36079057-613BB43B-BAAC-4FF7-80B3-62119CB59483Q36109712-C02232E7-931F-4A4A-8117-4937B2D1B0D5Q36180381-9F61FE33-FFFB-4ED7-9CC4-354E29471EDCQ36270042-CA549618-DD5E-4D8D-A12C-82AA3BA1CCEAQ36326247-FB436656-B5BF-41D1-9FBD-FA5FECBD4CE6Q36466104-29CCBEA7-4D28-42D5-84A3-D5A34C3FCA0BQ36545318-92C26CB7-9C1B-4FD0-8CB7-C37C666D1F6AQ36557412-C9258F58-36A6-4740-92C9-56F149395538Q36594041-CBD7BCAC-D7B9-4D33-BE39-B1206FF94D57Q36594649-0815C0E7-7157-4DB3-A0A6-C767302BE6BCQ36606222-6B9A1B6D-82B5-4ED4-84A1-779A3D556602Q36618876-2A46FE86-2336-476A-9E81-FFB4579A46B7Q36839866-06758D48-70C5-4013-8E5B-40A8694B505AQ36852491-2CCB32FE-FE90-4745-B1A6-87BC076FB932Q36921180-E9E0D14D-87E6-4B62-8D60-FE0F038F3D52Q36997381-FA502358-EB36-4FFC-B4BE-FC900F81F203Q37031859-C9380CFA-32BC-42E4-B6DE-3DBCDA7D4546Q37132029-833C9453-527D-4239-ADFC-8BC0DD350376Q37282991-C1423530-E429-42BC-BC77-BC6B91CF090AQ37291716-FA35EB23-4973-49E4-A84C-BF739EEFE755Q37326766-49F39074-AB32-4398-BAA6-4D5348E31E2CQ37553760-45016DC0-420B-4E93-8D89-6F7948219001Q37594104-D24A0F22-5015-4C5A-B3B9-2757E77E3640Q37683384-1E0338C4-C52D-47AD-BE32-701C39341D22Q38106675-9421CCB3-4158-4BB3-AD2B-3783E44AC5B5Q38112400-F7E5D593-5C53-4CA8-90E9-52712BC926DAQ38113212-C0F55930-D0C1-471C-8F13-5EC85562A081Q38243890-B32DE35D-9780-4982-816D-AC7420567F6B
P2860
The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
The iron chelators Dp44mT and ...... ream-regulated gene 1 (NDRG1).
@en
The iron chelators Dp44mT and ...... yc downstream-regulated gene 1
@nl
type
label
The iron chelators Dp44mT and ...... ream-regulated gene 1 (NDRG1).
@en
The iron chelators Dp44mT and ...... yc downstream-regulated gene 1
@nl
prefLabel
The iron chelators Dp44mT and ...... ream-regulated gene 1 (NDRG1).
@en
The iron chelators Dp44mT and ...... yc downstream-regulated gene 1
@nl
P2093
P2860
P356
P1476
The iron chelators Dp44mT and ...... ream-regulated gene 1 (NDRG1).
@en
P2093
Daohai Zhang
Minhua Zheng
Zaklina Kovacevic
Zhiqiang Chen
P2860
P304
17016-17028
P356
10.1074/JBC.M112.350470
P407
P577
2012-03-27T00:00:00Z