Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line
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MicroRNAs Expressed during Viral Infection: Biomarker Potential and Therapeutic ConsiderationsThe molecular basis of herpes simplex virus latencyRole of chromatin during herpesvirus infections.A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivationThe effects of viral load on pseudorabies virus gene expressionImmunohistochemical analysis of primary sensory neurons latently infected with herpes simplex virus type 1.Long-term transgene expression in mice infected with a herpes simplex virus type 1 mutant severely impaired for immediate-early gene expression.Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latencySmall non-coding RNAs encoded within the herpes simplex virus type 1 latency associated transcript (LAT) cooperate with the retinoic acid inducible gene I (RIG-I) to induce beta-interferon promoter activity and promote cell survival.Three herpes simplex virus type 1 latency-associated transcript mutants with distinct and asymmetric effects on virulence in mice compared with rabbits.The 2.2-kilobase latency-associated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic miceHerpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors.Lytic gene expression is frequent in HSV-1 latent infection and correlates with the engagement of a cell-intrinsic transcriptional responseNeither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virusRegions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo.LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans.The stable 2.0-kilobase intron of the herpes simplex virus type 1 latency-associated transcript does not function as an antisense repressor of ICP0 in nonneuronal cellsTranscription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters.Herpes simplex virus type 1 latently infected neurons differentially express latency-associated and ICP0 transcripts.Herpes simplex virus type 1 and bovine herpesvirus 1 latency.Effects of thyroid hormone on HSV-1 gene regulation: implications in the control of viral latency and reactivation.Herpes simplex virus latency-associated transcript sequence downstream of the promoter influences type-specific reactivation and viral neurotropism.HSV-1 miR-H6 inhibits HSV-1 replication and IL-6 expression in human corneal epithelial cells in vitro.The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected NeuronsInfluence of herpes simplex virus 1 latency-associated transcripts on the establishment and maintenance of latency in the ROSA26R reporter mouse modelHerpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal gangliaU94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in cultureTransgenic mouse with the herpes simplex virus type 1 latency-associated gene: expression and function of the transgeneInvestigation of the mechanism by which herpes simplex virus type 1 LAT sequences modulate preferential establishment of latent infection in mouse trigeminal ganglia.Two small RNAs encoded within the first 1.5 kilobases of the herpes simplex virus type 1 latency-associated transcript can inhibit productive infection and cooperate to inhibit apoptosis.Construction of a herpes simplex virus type 1 mutant with only a three-nucleotide change in the branchpoint region of the latency-associated transcript (LAT) and the stability of its two-kilobase LAT intron.Promyelocytic leukemia-nuclear body proteins: herpesvirus enemies, accomplices, or both?Regulation of human cytomegalovirus transcription in latency: beyond the major immediate-early promoterExpression of the herpes simplex virus type 1 latency-associated transcripts does not influence latency establishment of virus mutants deficient for neuronal replication.Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival.A protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSVThyroid hormone controls the gene expression of HSV-1 LAT and ICP0 in neuronal cells.The half-life of the HSV-1 1.5-kb LAT intron is similar to the half-life of the 2.0-kb LAT intron.
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P2860
Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Herpes simplex virus type 1 la ...... levels in a neuronal cell line
@en
Herpes simplex virus type 1 la ...... evels in a neuronal cell line.
@nl
type
label
Herpes simplex virus type 1 la ...... levels in a neuronal cell line
@en
Herpes simplex virus type 1 la ...... evels in a neuronal cell line.
@nl
prefLabel
Herpes simplex virus type 1 la ...... levels in a neuronal cell line
@en
Herpes simplex virus type 1 la ...... evels in a neuronal cell line.
@nl
P2093
P2860
P1433
P1476
Herpes simplex virus type 1 la ...... levels in a neuronal cell line
@en
P2093
P2860
P304
P407
P577
1998-06-01T00:00:00Z