Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose.
about
Fermentanomics: Relating quality attributes of a monoclonal antibody to cell culture process variables and raw materials using multivariate data analysis.Designed Amino Acid Feed in Improvement of Production and Quality Targets of a Therapeutic Monoclonal Antibody.Ultrafast and high-throughput N-glycan analysis for monoclonal antibodies.Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches.Tailoring recombinant protein quality by rational media design.A system identification approach for developing model predictive controllers of antibody quality attributes in cell culture processes.Arabinosylation of recombinant human immunoglobulin-based protein therapeuticsThe enhancement of antibody concentration and achievement of high cell density CHO cell cultivation by adding nucleoside.Analysis of Tubespins as a suitable scale-down model of bioreactors for high cell density CHO cell culture.Glycosylation of monoclonal antibody products: Current status and future prospects.Modulation and modeling of monoclonal antibody N-linked glycosylation in mammalian cell perfusion reactors.Galactose supplementation enhance sialylation of recombinant Fc-fusion protein in CHO cell: an insight into the role of galactosylation in sialylation.Impact of cell culture on recombinant monoclonal antibody product heterogeneity.Effects of copper on CHO cells: cellular requirements and product quality considerations.Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation.Modulating carbohydrate-protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology.A high-yielding CHO transient system: coexpression of genes encoding EBNA-1 and GS enhances transient protein expression.CHO cell line specific prediction and control of recombinant monoclonal antibody N-glycosylation.Galactosylation variations in marketed therapeutic antibodies.A simultaneous assessment metric for MAb quantity and glycan quality.Marketing approval of mogamulizumab: a triumph for glyco-engineering.Main Quality Attributes of Monoclonal Antibodies and Effect of Cell Culture ComponentsManganese increases high mannose glycoform on monoclonal antibody expressed in CHO when glucose is absent or limiting: Implications for use of alternate sugars.Chemically defined media modifications to lower tryptophan oxidation of biopharmaceuticals.Predictive glycoengineering of biosimilars using a Markov chain glycosylation model.A framework for real-time glycosylation monitoring (RT-GM) in mammalian cell culture.Process parameters impacting product quality.Identification of manipulated variables for a glycosylation control strategy.Solid-Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies.Animal Cell Expression Systems.Identifying a robust design space for glycosylation during monoclonal antibody production.Controlling the time evolution of mAb N-linked glycosylation, Part I: Microbioreactor experiments.Combining metabolic and process engineering strategies to improve recombinant glycoprotein production and quality.Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates.One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody-drug conjugates.Development of a pre-glycoengineered CHO-K1 host cell line for the expression of antibodies with enhanced Fc mediated effector function.Engineer Medium and Feed for Modulating N-Glycosylation of Recombinant Protein Production in CHO Cell Culture.Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations.Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity.Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors.
P2860
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P2860
Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Modulation of antibody galacto ...... anese chloride, and galactose.
@en
Modulation of antibody galacto ...... anese chloride, and galactose.
@nl
type
label
Modulation of antibody galacto ...... anese chloride, and galactose.
@en
Modulation of antibody galacto ...... anese chloride, and galactose.
@nl
prefLabel
Modulation of antibody galacto ...... anese chloride, and galactose.
@en
Modulation of antibody galacto ...... anese chloride, and galactose.
@nl
P2093
P2860
P356
P1476
Modulation of antibody galacto ...... anese chloride, and galactose.
@en
P2093
Carrie Shultz
Ewald T J van den Bremer
Jackie J Eckblad
Jolanda Gerritsen
Joseph Brown
Kent Vickerman
Michael J Gramer
Patrick H C van Berkel
Patrick Priem
Ruth Donahue
P2860
P304
P356
10.1002/BIT.23075
P577
2011-02-18T00:00:00Z